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BIOMARKER:

RB1 deletion

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Entrez ID:

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RB1 deletion	Estrogen Receptor Positive Breast Cancer	RB1 deletion	Estrogen Receptor Positive Breast Cancer	GSK3326595 Sensitive: D – Preclinical AACR 2023 - 1 week (New D) GSK3326595 Sensitive : D AACR 2023 - 1wk	GSK3326595 Sensitive: D – Preclinical AACR 2023 - 1 week GSK3326595 Sensitive : D AACR 2023 - 1 week - (New D)
RB1 deletion	Prostate Cancer	RB1 deletion	Prostate Cancer	abiraterone acetate Resistant: B - Late Trials abiraterone acetate Resistant : B	abiraterone acetate Resistant: B - Late Trials abiraterone acetate Resistant : B
RB1 deletion	Prostate Cancer	RB1 deletion	Prostate Cancer	enzalutamide capsule Resistant: B - Late Trials enzalutamide capsule Resistant : B	enzalutamide capsule Resistant: B - Late Trials enzalutamide capsule Resistant : B
RB1 deletion	Hormone Receptor Positive Breast Cancer	RB1 deletion	Hormone Receptor Positive Breast Cancer	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3
RB1 deletion	Melanoma	RB1 deletion	Melanoma	palbociclib Resistant: D – Preclinical palbociclib Resistant : D	palbociclib Resistant: D – Preclinical palbociclib Resistant : D
RB1 deletion	Mesothelioma	RB1 deletion	Mesothelioma	NBL-001 Sensitive: D – Preclinical NBL-001 Sensitive : D	NBL-001 Sensitive: D – Preclinical NBL-001 Sensitive : D
RB1 deletion	Mesothelioma	RB1 deletion	Mesothelioma	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D	MLN8237 Sensitive: D – Preclinical MLN8237 Sensitive : D
RB1 deletion	Mantle Cell Lymphoma	RB1 deletion	Mantle Cell Lymphoma	palbociclib Sensitive: D – Preclinical palbociclib Sensitive : D	palbociclib Sensitive: D – Preclinical palbociclib Sensitive : D
RB1 deletion	Ovarian Cancer	RB1 deletion	Ovarian Cancer	SRA515 Sensitive: D – Preclinical SRA515 Sensitive : D	SRA515 Sensitive: D – Preclinical SRA515 Sensitive : D
RB1 deletion	Ovarian Cancer	RB1 deletion	Ovarian Cancer	palbociclib + SRA515 Sensitive: D – Preclinical palbociclib + SRA515 Sensitive : D	palbociclib + SRA515 Sensitive: D – Preclinical palbociclib + SRA515 Sensitive : D
RB1 deletion	Estrogen Receptor Positive Breast Cancer	RB1 deletion	Estrogen Receptor Positive Breast Cancer	IGM-9427 Sensitive: D – Preclinical IGM-9427 Sensitive : D	IGM-9427 Sensitive: D – Preclinical IGM-9427 Sensitive : D
RB1 deletion	Estrogen Receptor Positive Breast Cancer	RB1 deletion	Estrogen Receptor Positive Breast Cancer	WEE1 inhibitor + Aurora kinase inhibitor Sensitive: D – Preclinical WEE1 inhibitor + Aurora kinase inhibitor Sensitive : D	WEE1 inhibitor + Aurora kinase inhibitor Sensitive: D – Preclinical WEE1 inhibitor + Aurora kinase inhibitor Sensitive : D