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Association details:
| Biomarker: | RET C634W |
|---|---|
| Cancer: | Thyroid Gland Medullary Carcinoma |
| Drug: | RAF265 (BRAF inhibitor, VEGFR-2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer
Excerpt:
In addition, RAF265 had significant RET inhibitory activity (IC₅₀ = 25-50 nmol/L for RET(C634W)).
DOI:
10.1158/1078-0432.CCR-11-0933
