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BIOMARKER:
PTEN mutation
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Other names: PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10, Mitochondrial Phosphatase And Tensin Protein Alpha, Phosphatase And Tensin-Like Protein, Protein Tyrosine Phosphatase, Mitochondrial PTENalpha, PTENbeta, PTEN1, CWS1, GLM2, MHAM
Entrez ID:
Related biomarkers:
PTEN mutation
Triple Negative Breast Cancer
GDC-0068
Sensitive
:
B
PTEN mutation
Prostate Cancer
bicalutamide
Sensitive
:
B
PTEN mutation
CRC
panitumumab
Sensitive
:
B
PTEN mutation
GBM
atezolizumab + GDC-0068
Sensitive
:
C3
PTEN mutation
Triple Negative Breast Cancer
pembrolizumab
Resistant
:
C3
PTEN mutation
Triple Negative Breast Cancer
atezolizumab
Resistant
:
C3
PTEN mutation
Endometrial Cancer
LY3023414
Sensitive
:
C3
PTEN mutation
Hormone Receptor Positive Breast Cancer
alpelisib
Resistant
:
C3
PTEN mutation
HER2 Negative Breast Cancer
talazoparib
Sensitive
:
C3
PTEN mutation
CRC
cetuximab
Resistant
:
C3
PTEN mutation
Prostate Cancer
abiraterone acetate + GDC-0068
Resistant
:
C3
PTEN mutation
Melanoma
Immunotherapy
Resistant
:
C3
PTEN mutation
Estrogen Receptor Positive Breast Cancer
AZD5363
Sensitive
:
C3
PTEN mutation
Melanoma
vemurafenib
Resistant
:
C4
PTEN mutation
Pancreatic Cancer
MK-2206
Sensitive
:
C4
PTEN mutation
GBM
MLN4924
Resistant
:
D
PTEN mutation
Glioma
MLN4924
Resistant
:
D
PTEN mutation
Prostate Cancer
dasatinib + AZD8055
Sensitive
:
D
PTEN mutation
CRC
PARP inhibitor
Resistant
:
D
PTEN mutation
Breast Cancer
TAK-228
Sensitive
:
D
PTEN mutation
Endometrial Cancer
AZD6482
Resistant
:
D
PTEN mutation
Endometrial Cancer
GSK2636771
Resistant
:
D
PTEN mutation
Endometrial Cancer
GDC-0941
Sensitive
:
D
PTEN mutation
Endometrial Cancer
RTB101
Sensitive
:
D
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