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PRMT5 inhibitor

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PRMT5 inhibitor

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MTAP deletion	Solid Tumor	MTAP deletion	Solid Tumor	TNG908 Sensitive: C2 – Inclusion Criteria TNG908 Sensitive : C2	TNG908 Sensitive: C2 – Inclusion Criteria TNG908 Sensitive : C2
MTAP deletion	Solid Tumor	MTAP deletion	Solid Tumor	TNG462 Sensitive: C2 – Inclusion Criteria TNG462 Sensitive : C2	TNG462 Sensitive: C2 – Inclusion Criteria TNG462 Sensitive : C2
IDH2 mutation	Glioma	IDH2 mutation	Glioma	P-500 Sensitive: C3 – Early Trials P-500 Sensitive : C3	P-500 Sensitive: C3 – Early Trials P-500 Sensitive : C3
IDH1 mutation	Glioma	IDH1 mutation	Glioma	P-500 Sensitive: C3 – Early Trials P-500 Sensitive : C3	P-500 Sensitive: C3 – Early Trials P-500 Sensitive : C3
MTAP deletion	Esophageal Cancer	MTAP deletion	Esophageal Cancer	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3
MTAP deletion	Renal Cell Carcinoma	MTAP deletion	Renal Cell Carcinoma	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3
MTAP deletion	Gallbladder Cancer	MTAP deletion	Gallbladder Cancer	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3
MTAP deletion	Pancreatic Cancer	MTAP deletion	Pancreatic Cancer	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3
MTAP deletion	Ovarian Cancer	MTAP deletion	Ovarian Cancer	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3	AMG 193 Sensitive: C3 – Early Trials AMG 193 Sensitive : C3
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23	Gallbladder Cancer	TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23	Gallbladder Cancer	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4
NF1 mutation + CDKN2A deletion + CDKN2B deletion + MTAP deletion	Neurofibrosarcoma	NF1 mutation + CDKN2A deletion + CDKN2B deletion + MTAP deletion	Neurofibrosarcoma	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4
MTAP deletion + CDKN2A deletion + CDKN2B deletion + BAP1 deletion	Malignant Pleural Mesothelioma	MTAP deletion + CDKN2A deletion + CDKN2B deletion + BAP1 deletion	Malignant Pleural Mesothelioma	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4	BMS‐986504 Sensitive: C4 – Case Studies BMS‐986504 Sensitive : C4