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Association details:
| Biomarker: | MTAP deletion |
|---|---|
| Cancer: | Renal Cell Carcinoma |
| Drug: | AMG 193 (PRMT5 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
AMG 193 Effective in Multiple Tumor Types
Published date:
10/17/2023
Excerpt:
In a phase I trial of the MTA-cooperative PRMT5 inhibitor AMG 193, five of 39 patients with advanced MTAP-deleted solid tumors who had scans following initial treatment experienced partial responses...tumor types-esophageal, pancreatic, renal cell, gallbladder, and ovarian Sertoli-Leydig cell cancer.
DOI:
10.1158/2159-8290.CD-NB2023-0079
