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BIOMARKER:
NRAS Q61
i
Other names:
NRAS1, HRAS1, N-Ras Protein Part 4, Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog, NRAS, Neuroblastoma RAS Viral Oncogene Homolog, NRAS Proto-Oncogene, GTPase
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Entrez ID:
4893
Related biomarkers:
Expression
Mutation
CNA
Others
‹
EGFR exon 19 deletion + NRAS Q61K (3)
PD-L1 expression + NRAS Q61R + BRAF D594N (2)
CDKN2A Negative + NRAS Mutation (1)
Chr t(11;14) + NRAS mutation (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
MLL-AFF1 fusion + NRAS mutation (1)
NRAS mutation + BRAF wild-type (1)
NRAS wild-type + NOTCH4 mutation (1)
EGFR exon 19 deletion + NRAS Q61K (3)
PD-L1 expression + NRAS Q61R + BRAF D594N (2)
CDKN2A Negative + NRAS Mutation (1)
Chr t(11;14) + NRAS mutation (1)
KRAS wild-type + NRAS wild-type + MSI-H/dMMR (1)
MLL-AFF1 fusion + NRAS mutation (1)
NRAS mutation + BRAF wild-type (1)
NRAS wild-type + NOTCH4 mutation (1)
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Associations
News
Trials
VERI cancer hierarchy
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NRAS Q61
Colorectal Cancer
NRAS Q61
Colorectal Cancer
cetuximab
Resistant: A1 - Approval
cetuximab
Resistant
:
A1
cetuximab
Resistant: A1 - Approval
cetuximab
Resistant
:
A1
NRAS Q61
Colorectal Cancer
NRAS Q61
Colorectal Cancer
panitumumab
Resistant: A1 - Approval
panitumumab
Resistant
:
A1
panitumumab
Resistant: A1 - Approval
panitumumab
Resistant
:
A1
NRAS Q61
Melanoma
NRAS Q61
Melanoma
vemurafenib
Resistant: C3 – Early Trials
vemurafenib
Resistant
:
C3
vemurafenib
Resistant: C3 – Early Trials
vemurafenib
Resistant
:
C3
NRAS Q61
Colorectal Cancer
NRAS Q61
Colorectal Cancer
binimetinib
Sensitive: C3 – Early Trials
binimetinib
Sensitive
:
C3
binimetinib
Sensitive: C3 – Early Trials
binimetinib
Sensitive
:
C3
NRAS Q61
Melanoma
NRAS Q61
Melanoma
HL-085
Sensitive: C3 – Early Trials
HL-085
Sensitive
:
C3
HL-085
Sensitive: C3 – Early Trials
HL-085
Sensitive
:
C3
NRAS Q61
Melanoma
NRAS Q61
Melanoma
PD-0325901 + BGB-3245
Sensitive: D – Preclinical
PD-0325901 + BGB-3245
Sensitive
:
D
PD-0325901 + BGB-3245
Sensitive: D – Preclinical
PD-0325901 + BGB-3245
Sensitive
:
D
NRAS Q61
Melanoma
NRAS Q61
Melanoma
PD-0325901 + BGB-283
Sensitive: D – Preclinical
PD-0325901 + BGB-283
Sensitive
:
D
PD-0325901 + BGB-283
Sensitive: D – Preclinical
PD-0325901 + BGB-283
Sensitive
:
D
NRAS Q61
Melanoma
NRAS Q61
Melanoma
sorafenib
Sensitive: D – Preclinical
sorafenib
Sensitive
:
D
sorafenib
Sensitive: D – Preclinical
sorafenib
Sensitive
:
D
NRAS Q61
Cholangiocarcinoma
NRAS Q61
Cholangiocarcinoma
NXP800
Sensitive: D – Preclinical
NXP800
Sensitive
:
D
NXP800
Sensitive: D – Preclinical
NXP800
Sensitive
:
D
NRAS Q61
Melanoma
NRAS Q61
Melanoma
cobimetinib + roflumilast
Sensitive: D – Preclinical
cobimetinib + roflumilast
Sensitive
:
D
cobimetinib + roflumilast
Sensitive: D – Preclinical
cobimetinib + roflumilast
Sensitive
:
D
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