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Association details:
| Biomarker: | NOTCH1 mutation |
|---|---|
| Cancer: | T Acute Lymphoblastic Leukemia |
| Drug: | IACS-010759 (Electron transport complex I inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism
Published date:
11/06/2019
Excerpt:
In this study we examined metabolic vulnerabilities of NOTCH1-driven T-ALL and tested pre-clinical efficacy of novel mitochondrial complex I (OxPhosi) IACS-010759 and of glutaminase inhibitor CB-839 (GLSi) in T-ALL models including Notch1-mutated T-ALL cell lines...This translated into significant reduction of leukemia burden and extension of overall survival in vivo (p<0.0001) in Notch1-mutated T-ALL PDX models (n=2) with IACS-010759/CB-839 co-treatment…
DOI:
10.1182/blood-2019-128930
