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BIOMARKER:

MYCN amplification

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Other names: MYCN, MYCN Proto-Oncogene BHLH Transcription Factor, V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog, Class E Basic Helix-Loop-Helix Protein 37, N-Myc Proto-Oncogene Protein, BHLHe37, NMYC, Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene, Neuroblastoma MYC Oncogene, Oncogene NMYC, BHLHE37, MODED, N-Myc, ODED
Entrez ID:
Related biomarkers:
MYCN amplification
Small Cell Lung Cancer
AZD1775
Sensitive: C2 – Inclusion Criteria
MYCN amplification
Prostate Cancer
abiraterone acetate
Resistant: C3 – Early Trials
MYCN amplification
Prostate Cancer
enzalutamide
Resistant: C3 – Early Trials
MYCN amplification
Pancreatic Cancer
encorafenib + binimetinib
Sensitive: C4 – Case Studies
MYCN amplification
Neuroblastoma
GSK2816126 + MTX110
Sensitive: D – Preclinical
MYCN amplification
Neuroblastoma
OTX015
Sensitive: D – Preclinical
MYCN amplification
Neuroblastoma
JQ-1 + MTX110
Sensitive: D – Preclinical
MYCN amplification
Neuroblastoma
brigatinib
Resistant: D – Preclinical
MYCN amplification
Neuroblastoma
crizotinib
Resistant: D – Preclinical
MYCN amplification
Medulloblastoma
sonidegib
Resistant: D – Preclinical
MYCN amplification
Neuroblastoma
DHODH inhibitor
Sensitive: D – Preclinical
MYCN amplification
Neuroblastoma
olaparib + MK-8776
Sensitive: D – Preclinical
MYCN amplification
Medulloblastoma
olaparib + MK-8776
Sensitive: D – Preclinical