^
No biomarker
Neuroblastoma
dinutuximab beta
Sensitive
:
A1
No biomarker
Neuroblastoma
doxorubicin hydrochloride
Sensitive
:
A1
No biomarker
Neuroblastoma
melphalan
Sensitive
:
A1
No biomarker
Neuroblastoma
dinutuximab
Sensitive
:
A1
No biomarker
Neuroblastoma
cyclophosphamide
Sensitive
:
A1
No biomarker
Neuroblastoma
naxitamab
Sensitive
:
A1
ALK positive
Neuroblastoma
lorlatinib
Sensitive
:
C1
ALK positive
Neuroblastoma
crizotinib
Sensitive
:
C3
ALK R1275Q
Neuroblastoma
crizotinib
Sensitive
:
C3
ATRX mutation
Neuroblastoma
AZD1775
Sensitive
:
C3
ALK rearrangement + ALK R1275Q + TP53 mutation
Neuroblastoma
crizotinib
Resistant
:
C4
PGBD5 overexpression
Neuroblastoma
cisplatin
Sensitive
:
D
PGBD5 overexpression
Neuroblastoma
AZD6738
Sensitive
:
D
PGBD5 underexpression
Neuroblastoma
AZD6738
Sensitive
:
D
ALK R1275Q
Neuroblastoma
TAE-684
Resistant
:
D
MYCN amplification
Neuroblastoma
panobinostat + GSK2816126
Sensitive
:
D
MYCN amplification
Neuroblastoma
OTX015
Sensitive
:
D
MYCN amplification
Neuroblastoma
JQ-1 + panobinostat
Sensitive
:
D
MYCN amplification
Neuroblastoma
brigatinib
Resistant
:
D
MYCN amplification
Neuroblastoma
crizotinib
Resistant
:
D
ALK F1174L
Neuroblastoma
crizotinib
Resistant
:
D
ALK F1174L
Neuroblastoma
AZD3463
Sensitive
:
D
ALK F1174L
Neuroblastoma
alectinib
Sensitive
:
D
ALK amplification
Neuroblastoma
alectinib
Sensitive
:
D
ALK F1245C
Neuroblastoma
lorlatinib
Sensitive
:
D
ALK F1174C
Neuroblastoma
lorlatinib
Sensitive
:
D
ALK F1174L
Neuroblastoma
TAE-684
Sensitive
:
D
MYCN amplification + ALK rearrangement
Neuroblastoma
brigatinib
Sensitive
:
D
MYCN amplification + ALK F1174V
Neuroblastoma
brigatinib
Sensitive
:
D
MYCN amplification + ALK F1174V
Neuroblastoma
crizotinib
Sensitive
:
D
NF1 underexpression
Neuroblastoma
binimetinib
Sensitive
:
D
MYCN amplification + ALK F1174L
Neuroblastoma
lorlatinib
Sensitive
:
D