^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Abstract 800: Exploiting the proteasome to overcome RAS and WT1 mutation mediated resistance to FLT-3 inhibition in acute myeloid leukemia

Published date:
06/23/2020
Excerpt:
mFLT-3 samples with co-mutations in DNMT3A, NPM1 or tMLL were very sensitive to TAK-659 (IC50 <75 nM) but much less sensitive to Ixazomib alone (IC50>100nM).
DOI:
10.1158/1538-7445.AM2020-800