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BIOMARKER:
MET mutation
i
Other names:
DFNB97, AUTS9, RCCP2, C-Met, HGFR, HGF Receptor, Met Proto-Oncogene, HGF/SF Receptor, Proto-Oncogene C-Met, Scatter Factor Receptor, Tyrosine-Protein Kinase Met, Hepatocyte Growth Factor Receptor, MET, MET Proto-Oncogene, Receptor Tyrosine Kinase
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Entrez ID:
4233
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
MET exon 14 mutation (33)
MET H1094Y (3)
MET N375S (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
MET exon 14 mutation (33)
MET H1094Y (3)
MET N375S (3)
EGFR mutation + MET mutation (2)
MET D1010N (2)
MET D1228N (2)
MET D1228V (2)
MET F1200I (2)
MET exon 14 mutation + EGFR exon 20 insertion (2)
EGFR T790M + MET mutation (1)
EGFR exon 21 deletion + EGFR L858R + MET Exon 14 mutation (1)
EGFR mutation + MET Y1003N (1)
EGFR wild-type + MET wild-type (1)
MET D1010H (1)
MET D1010Y (1)
MET D1028N (1)
MET R1004G (1)
MET Y1003C (1)
MET Y1021H (1)
MET Y1230C (1)
MET exon 14 mutation + KRAS G12A (1)
MET exon 14 mutation + TP53 mutation (1)
MET mutation + AXL mutation (1)
MET D1228Y (0)
MET exon 14 skipping mutation + EGFR G709T (0)
MET D1228H (0)
MET Y1230C (0)
ROS rearrangement + MET D1246N (0)
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Associations
News
Trials
VERI cancer hierarchy
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MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
savolitinib
Sensitive: B - Late Trials
savolitinib
Sensitive
:
B
savolitinib
Sensitive: B - Late Trials
savolitinib
Sensitive
:
B
MET mutation
Gastric Cancer
MET mutation
Gastric Cancer
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
TPX-0022
Sensitive: C2 – Inclusion Criteria
TPX-0022
Sensitive
:
C2
MET mutation
Non Small Cell Lung Cancer
MET mutation
Non Small Cell Lung Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
cabozantinib capsule
Sensitive: C2 – Inclusion Criteria
cabozantinib capsule
Sensitive
:
C2
cabozantinib capsule
Sensitive: C2 – Inclusion Criteria
cabozantinib capsule
Sensitive
:
C2
MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
MET mutation
Non Small Cell Lung Cancer
MET mutation
Non Small Cell Lung Cancer
MGCD265
Sensitive: C2 – Inclusion Criteria
MGCD265
Sensitive
:
C2
MGCD265
Sensitive: C2 – Inclusion Criteria
MGCD265
Sensitive
:
C2
MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
c-MET inhibitor
Sensitive: C3 – Early Trials
c-MET inhibitor
Sensitive
:
C3
c-MET inhibitor
Sensitive: C3 – Early Trials
c-MET inhibitor
Sensitive
:
C3
MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
sunitinib
Sensitive: C3 – Early Trials
sunitinib
Sensitive
:
C3
sunitinib
Sensitive: C3 – Early Trials
sunitinib
Sensitive
:
C3
MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
everolimus
Sensitive: C3 – Early Trials
everolimus
Sensitive
:
C3
everolimus
Sensitive: C3 – Early Trials
everolimus
Sensitive
:
C3
MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
GSK1363089
Sensitive: C3 – Early Trials
GSK1363089
Sensitive
:
C3
GSK1363089
Sensitive: C3 – Early Trials
GSK1363089
Sensitive
:
C3
MET mutation
Non Small Cell Lung Cancer
MET mutation
Non Small Cell Lung Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
MET mutation
Renal Cell Carcinoma
MET mutation
Renal Cell Carcinoma
durvalumab + savolitinib
Sensitive: C3 – Early Trials
durvalumab + savolitinib
Sensitive
:
C3
durvalumab + savolitinib
Sensitive: C3 – Early Trials
durvalumab + savolitinib
Sensitive
:
C3
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