^
Association details:
| Biomarker: | MCL1 amplification |
|---|---|
| Cancer: | Ewing Sarcoma |
| Drug: | alvocidib (DSP-2033) (CDK4 inhibitor, CDK6 inhibitor, CDK9 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
5984 / 13 - CDK9 inhibition as a potential therapeutic strategy in Ewing sarcoma
Published date:
03/15/2023
Excerpt:
MCL-1 amplified EWS cells were observed significantly more sensitive to alvocidib than MCL-1 diploid EWS cells in the EWS cells from PDX models (p=0.004).
