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DRUG CLASS:

CDK9 inhibitor

DRUG CLASS:

CDK9 inhibitor

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No biomarker	Peripheral T-cell Lymphoma	No biomarker	Peripheral T-cell Lymphoma	SLS009 Sensitive: B - Late Trials SLS009 Sensitive : B	SLS009 Sensitive: B - Late Trials SLS009 Sensitive : B
IDH2 mutation	Glioma	IDH2 mutation	Glioma	TG02 Sensitive: C2 – Inclusion Criteria TG02 Sensitive : C2	TG02 Sensitive: C2 – Inclusion Criteria TG02 Sensitive : C2
IDH1 mutation	Glioma	IDH1 mutation	Glioma	TG02 Sensitive: C3 – Early Trials TG02 Sensitive : C3	TG02 Sensitive: C3 – Early Trials TG02 Sensitive : C3
CDK1 overexpression	Adrenal Cortex Carcinoma	CDK1 overexpression	Adrenal Cortex Carcinoma	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
CDK2 overexpression	Adrenal Cortex Carcinoma	CDK2 overexpression	Adrenal Cortex Carcinoma	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
KRAS G12V	Colon Cancer	KRAS G12V	Colon Cancer	CDK9 inhibitor Sensitive: D – Preclinical CDK9 inhibitor Sensitive : D	CDK9 inhibitor Sensitive: D – Preclinical CDK9 inhibitor Sensitive : D
MCL1 expression	Acute Myelogenous Leukemia	MCL1 expression	Acute Myelogenous Leukemia	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
MCL1 expression	Myelodysplastic Syndrome	MCL1 expression	Myelodysplastic Syndrome	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
KRAS Q61H	Non Small Cell Lung Cancer	KRAS Q61H	Non Small Cell Lung Cancer	ME-522 Sensitive: D – Preclinical ME-522 Sensitive : D	ME-522 Sensitive: D – Preclinical ME-522 Sensitive : D
KRAS G12V	Colorectal Cancer	KRAS G12V	Colorectal Cancer	ME-522 Sensitive: D – Preclinical ME-522 Sensitive : D	ME-522 Sensitive: D – Preclinical ME-522 Sensitive : D
KRAS G13D	Colorectal Cancer	KRAS G13D	Colorectal Cancer	ME-522 Sensitive: D – Preclinical ME-522 Sensitive : D	ME-522 Sensitive: D – Preclinical ME-522 Sensitive : D
ASXL1 mutation	Myelodysplastic Syndrome	ASXL1 mutation	Myelodysplastic Syndrome	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D