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DRUG:

alvocidib (DSP-2033)

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Company:

Sumitomo Pharma

Drug class:

CDK4 inhibitor, CDK6 inhibitor, CDK9 inhibitor

Related drugs:

CDK1 overexpression	Adrenal Cortex Carcinoma	CDK1 overexpression	Adrenal Cortex Carcinoma	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
CDK2 overexpression	Adrenal Cortex Carcinoma	CDK2 overexpression	Adrenal Cortex Carcinoma	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
MCL1 expression	Acute Myelogenous Leukemia	MCL1 expression	Acute Myelogenous Leukemia	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
MCL1 expression	Myelodysplastic Syndrome	MCL1 expression	Myelodysplastic Syndrome	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
ASXL1 mutation	Myelodysplastic Syndrome	ASXL1 mutation	Myelodysplastic Syndrome	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
ZRSR2 mutation	Myelodysplastic Syndrome	ZRSR2 mutation	Myelodysplastic Syndrome	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
ASXL1 Y588X	Myelodysplastic Syndrome	ASXL1 Y588X	Myelodysplastic Syndrome	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D
MCL1 amplification	Ewing Sarcoma	MCL1 amplification	Ewing Sarcoma	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D	DSP-2033 Sensitive: D – Preclinical DSP-2033 Sensitive : D