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BIOMARKER:
KRAS G12V
i
Other names:
KRAS, KRAS1, KRAS2, Kirsten rat sarcoma viral oncogene homolog
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Entrez ID:
3845
Related biomarkers:
Expression
Mutation
CNA
Others
‹
KRAS mutation (239)
KRAS G12C (159)
KRAS G12D (64)
KRAS wild-type (26)
KRAS G13D (22)
KRAS G12R (18)
RAS wild-type (17)
KRAS G12A (14)
KRAS G12 (10)
KRAS G12S (9)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
TP53 mutation + KRAS mutation (6)
KRAS G12C + STK11 mutation (5)
EGFR mutation + KRAS mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR T790M + KRAS mutation (2)
EGFR V802I + KRAS mutation (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + EGFR wild-type (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
EGFR T790M + KRAS G12V (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
KRAS mutation (239)
KRAS G12C (159)
KRAS G12D (64)
KRAS wild-type (26)
KRAS G13D (22)
KRAS G12R (18)
RAS wild-type (17)
KRAS G12A (14)
KRAS G12 (10)
KRAS G12S (9)
KRAS G13 (8)
KRAS mutation + STK11 mutation (8)
KRAS Q61H (7)
KRAS exon 2 mutation (7)
TP53 mutation + KRAS mutation (6)
KRAS G12C + STK11 mutation (5)
EGFR mutation + KRAS mutation (4)
KRAS A146 (4)
KRAS A59T (4)
KRAS Q61 (4)
KRAS A146T (3)
KRAS G12C + TP53 mutation (3)
KRAS G12D + STK11 mutation (3)
KRAS Y96D (3)
KRAS Y96S (3)
EGFR T790M + KRAS mutation (2)
EGFR V802I + KRAS mutation (2)
KEAP1 mutation + KRAS mutation (2)
KRAS A146V (2)
KRAS A59 (2)
KRAS A59S (2)
KRAS G12C + KEAP1 mutation (2)
KRAS G12D + KRAS G12V (2)
KRAS G13A (2)
KRAS G13C (2)
KRAS G13D + BRAF mutation (2)
KRAS K117 (2)
KRAS Q99L (2)
KRAS R68M (2)
KRAS exon 12 mutation (2)
KRAS exon 2 wild-type (2)
KRAS exon 3 mutation (2)
KRAS exon 4 mutation (2)
KRAS mutation + EGFR wild-type (2)
KRAS mutation + STK11 mutation + KEAP1 mutation (2)
KRAS mutation + TP53 wild-type (2)
PIK3CA mutation + KRAS mutation (2)
STK11 mutation + KEAP1 mutation + KRAS G12C (2)
ALK rearrangement + EGFR D761N + KRAS V14I (1)
ALK rearrangement + KRAS mutation (1)
APC mutation + KRAS mutation (1)
ARID1A mutation+ KRAS G12C (1)
BRAF V600E + KRAS G12R (1)
DICER1 A1690Gfs*9 + DICER1 E1813Q + KRAS G12L (1)
EGFR T790M + KRAS G12V (1)
KIR2DS4 mutation + KRAS mutation (1)
KRAS G12A + BRAF D549N (1)
KRAS G12C + ATM wild-type (1)
KRAS G12C + KRAS G12V (1)
KRAS G12C + SMARCA4 wild-type (1)
KRAS G12D + DNMT3A C559fsX (1)
KRAS G12V + BRAF V600E (1)
KRAS G12V + STK11 mutation (1)
KRAS G12V + TP53 mutation + APC mutation (1)
KRAS G60D (1)
KRAS G61 (1)
KRAS G61H + KRAS G12A (1)
KRAS N116H (1)
KRAS N116T (1)
KRAS Q22X (1)
KRAS Q61K (1)
KRAS Q61L (1)
KRAS S89P (1)
KRAS V12 (1)
KRAS codon 12 mutation + KRAS codon 13 mutation + EGFR mutation (1)
KRAS exon 13 mutation (1)
KRAS mutation + ATM mutation (1)
KRAS mutation + KEAP1 mutation (1)
KRAS mutation + SMARCA4 mutation (1)
KRAS mutation + STK11 deletion + KEAP1 deletion (1)
KRAS mutation + STK11 mutation + TP53 mutation (1)
KRAS mutation + U2AF1 mutation (1)
KRAS mutation + KMT2C mutation (1)
MAP2K1 G128D + KRAS mutation (1)
MET exon 14 mutation + KRAS G12A (1)
NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)
PIK3CA mutation + PTEN mutation + KRAS mutation (1)
PIK3CA wild-type + KRAS wild-type (1)
PTPN11 mutation + KRAS wild-type (1)
STK11 mutation + KEAP1 mutation + KRAS wild-type (1)
BRAF V600E + KRAS G12D (0)
CDKN2A mutation + CDKN2B mutation + KRAS mutation (0)
CDKN2A mutation + KRAS mutation (0)
KRAS A146P (0)
KRAS A59 (0)
KRAS G61H (0)
KRAS mutation + TP53 mutation (0)
›
Related tests:
therascreen® KRAS RGQ PCR Kit (5)
therascreen® KRAS RGQ PCR Kit (5)
Associations
News
Trials
VERI cancer hierarchy
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KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
panitumumab
Sensitive: B - Late Trials
panitumumab
Sensitive
:
B
panitumumab
Sensitive: B - Late Trials
panitumumab
Sensitive
:
B
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
cetuximab
Resistant: B - Late Trials
cetuximab
Resistant
:
B
KRAS G12V
Ovarian Serous Adenocarcinoma
KRAS G12V
Ovarian Serous Adenocarcinoma
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
KRAS G12V
Ovarian Cancer
KRAS G12V
Ovarian Cancer
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
VS-6766 + VS-6063
Sensitive: C2 – Inclusion Criteria
VS-6766 + VS-6063
Sensitive
:
C2
KRAS G12V
Solid Tumor
KRAS G12V
Solid Tumor
AFNT-211
Sensitive: C2 – Inclusion Criteria
AFNT-211
Sensitive
:
C2
AFNT-211
Sensitive: C2 – Inclusion Criteria
AFNT-211
Sensitive
:
C2
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
selumetinib
Sensitive: C3 – Early Trials
selumetinib
Sensitive
:
C3
selumetinib
Sensitive: C3 – Early Trials
selumetinib
Sensitive
:
C3
KRAS G12V
Spindle Cell Sarcoma
KRAS G12V
Spindle Cell Sarcoma
BAL3833
Sensitive: C3 – Early Trials
BAL3833
Sensitive
:
C3
BAL3833
Sensitive: C3 – Early Trials
BAL3833
Sensitive
:
C3
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
PD-L1 inhibitor
Sensitive: C3 – Early Trials
PD-L1 inhibitor
Sensitive
:
C3
PD-L1 inhibitor
Sensitive: C3 – Early Trials
PD-L1 inhibitor
Sensitive
:
C3
KRAS G12V
Hepatocellular Cancer
KRAS G12V
Hepatocellular Cancer
sorafenib + BAY86-9766
Sensitive: C3 – Early Trials
sorafenib + BAY86-9766
Sensitive
:
C3
sorafenib + BAY86-9766
Sensitive: C3 – Early Trials
sorafenib + BAY86-9766
Sensitive
:
C3
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
erlotinib
Resistant: C3 – Early Trials
erlotinib
Resistant
:
C3
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
VS-6766
Sensitive: C3 – Early Trials
VS-6766
Sensitive
:
C3
VS-6766
Sensitive: C3 – Early Trials
VS-6766
Sensitive
:
C3
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
RGX-202
Sensitive: C3 – Early Trials
RGX-202
Sensitive
:
C3
RGX-202
Sensitive: C3 – Early Trials
RGX-202
Sensitive
:
C3
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
bevacizumab + PCM-075
Sensitive: C3 – Early Trials
bevacizumab + PCM-075
Sensitive
:
C3
bevacizumab + PCM-075
Sensitive: C3 – Early Trials
bevacizumab + PCM-075
Sensitive
:
C3
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
Resistant: C3 – Early Trials
Resistant
:
C3
Resistant: C3 – Early Trials
Resistant
:
C3
KRAS G12V
Lung Non-Squamous Non-Small Cell Cancer
KRAS G12V
Lung Non-Squamous Non-Small Cell Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
nivolumab + rigosertib
Sensitive: C3 – Early Trials
nivolumab + rigosertib
Sensitive
:
C3
nivolumab + rigosertib
Sensitive: C3 – Early Trials
nivolumab + rigosertib
Sensitive
:
C3
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
KRAS G12V
Pancreatic Ductal Adenocarcinoma
KRAS G12V
Pancreatic Ductal Adenocarcinoma
gemcitabine + paclitaxel
Resistant: C3 – Early Trials
gemcitabine + paclitaxel
Resistant
:
C3
gemcitabine + paclitaxel
Resistant: C3 – Early Trials
gemcitabine + paclitaxel
Resistant
:
C3
KRAS G12V
Lung Adenocarcinoma
KRAS G12V
Lung Adenocarcinoma
osimertinib
Resistant: C4 – Case Studies
osimertinib
Resistant
:
C4
osimertinib
Resistant: C4 – Case Studies
osimertinib
Resistant
:
C4
KRAS G12V
Pancreatic Ductal Adenocarcinoma
KRAS G12V
Pancreatic Ductal Adenocarcinoma
anlotinib
Sensitive: C4 – Case Studies
anlotinib
Sensitive
:
C4
anlotinib
Sensitive: C4 – Case Studies
anlotinib
Sensitive
:
C4
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
AZ 628
Resistant: D – Preclinical
AZ 628
Resistant
:
D
AZ 628
Resistant: D – Preclinical
AZ 628
Resistant
:
D
KRAS G12V
Colon Cancer
KRAS G12V
Colon Cancer
CDK9 inhibitor
Sensitive: D – Preclinical
CDK9 inhibitor
Sensitive
:
D
CDK9 inhibitor
Sensitive: D – Preclinical
CDK9 inhibitor
Sensitive
:
D
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
selumetinib + AZ 628
Sensitive: D – Preclinical
selumetinib + AZ 628
Sensitive
:
D
selumetinib + AZ 628
Sensitive: D – Preclinical
selumetinib + AZ 628
Sensitive
:
D
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
selumetinib
Resistant: D – Preclinical
selumetinib
Resistant
:
D
selumetinib
Resistant: D – Preclinical
selumetinib
Resistant
:
D
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
palbociclib
Sensitive: D – Preclinical
palbociclib
Sensitive
:
D
palbociclib
Sensitive: D – Preclinical
palbociclib
Sensitive
:
D
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
JQ-1
Sensitive: D – Preclinical
JQ-1
Sensitive
:
D
JQ-1
Sensitive: D – Preclinical
JQ-1
Sensitive
:
D
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
sunitinib
Resistant: D – Preclinical
sunitinib
Resistant
:
D
sunitinib
Resistant: D – Preclinical
sunitinib
Resistant
:
D
KRAS G12V
Ovarian Cancer
KRAS G12V
Ovarian Cancer
trametinib
Sensitive: D – Preclinical
trametinib
Sensitive
:
D
trametinib
Sensitive: D – Preclinical
trametinib
Sensitive
:
D
KRAS G12V
Colorectal Cancer
KRAS G12V
Colorectal Cancer
ME-522
Sensitive: D – Preclinical
ME-522
Sensitive
:
D
ME-522
Sensitive: D – Preclinical
ME-522
Sensitive
:
D
KRAS G12V
Non Small Cell Lung Cancer
KRAS G12V
Non Small Cell Lung Cancer
pembrolizumab
Sensitive: D – Preclinical
pembrolizumab
Sensitive
:
D
pembrolizumab
Sensitive: D – Preclinical
pembrolizumab
Sensitive
:
D
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