IDH1 mutation

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Entrez ID:

3417

Related biomarkers:

Expression

Mutation

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IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	ivosidenib Sensitive: A1 - Approval ASCO 2023 - 4 days (New B) ivosidenib Sensitive : A1 ASCO 2023 - 4d	ivosidenib Sensitive: A1 - Approval ASCO 2023 - 4 days ivosidenib Sensitive : A1 ASCO 2023 - 4 days - (New B)
IDH1 mutation	Glioma	IDH1 mutation	Glioma	PRT811 Sensitive: C3 – Early Trials ASCO 2023 - 4 days (New C3) PRT811 Sensitive : C3 ASCO 2023 - 4d	PRT811 Sensitive: C3 – Early Trials ASCO 2023 - 4 days PRT811 Sensitive : C3 ASCO 2023 - 4 days - (New C3)
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	venetoclax Sensitive: A2 - Guideline EHA 2023 - 2 weeks (New C3) venetoclax Sensitive : A2 EHA 2023 - 2wk	venetoclax Sensitive: A2 - Guideline EHA 2023 - 2 weeks venetoclax Sensitive : A2 EHA 2023 - 2 weeks - (New C3)
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	olutasidenib Sensitive: A1 - Approval EHA 2023 - 2 weeks (New C3) olutasidenib Sensitive : A1 EHA 2023 - 2wk	olutasidenib Sensitive: A1 - Approval EHA 2023 - 2 weeks olutasidenib Sensitive : A1 EHA 2023 - 2 weeks - (New C3)
IDH1 mutation	Myelodysplastic Syndrome	IDH1 mutation	Myelodysplastic Syndrome	ivosidenib Sensitive: C1 - Off-label EHA 2023 - 2 weeks (New C3) ivosidenib Sensitive : C1 EHA 2023 - 2wk	ivosidenib Sensitive: C1 - Off-label EHA 2023 - 2 weeks ivosidenib Sensitive : C1 EHA 2023 - 2 weeks - (New C3)
IDH1 mutation	Cholangiocarcinoma	IDH1 mutation	Cholangiocarcinoma	ivosidenib Sensitive: A1 - Approval ivosidenib Sensitive : A1	ivosidenib Sensitive: A1 - Approval ivosidenib Sensitive : A1
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	temozolomide Sensitive: A2 - Guideline temozolomide Sensitive : A2	temozolomide Sensitive: A2 - Guideline temozolomide Sensitive : A2
IDH1 mutation	Sarcoma	IDH1 mutation	Sarcoma	ivosidenib Sensitive: A2 - Guideline ivosidenib Sensitive : A2	ivosidenib Sensitive: A2 - Guideline ivosidenib Sensitive : A2
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	PCV Sensitive: A2 - Guideline PCV Sensitive : A2	PCV Sensitive: A2 - Guideline PCV Sensitive : A2
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	cisplatin Sensitive: A2 - Guideline cisplatin Sensitive : A2	cisplatin Sensitive: A2 - Guideline cisplatin Sensitive : A2
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	carboplatin Sensitive: A2 - Guideline carboplatin Sensitive : A2	carboplatin Sensitive: A2 - Guideline carboplatin Sensitive : A2
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	etoposide IV Sensitive: A2 - Guideline etoposide IV Sensitive : A2	etoposide IV Sensitive: A2 - Guideline etoposide IV Sensitive : A2
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	bevacizumab Sensitive: A2 - Guideline bevacizumab Sensitive : A2	bevacizumab Sensitive: A2 - Guideline bevacizumab Sensitive : A2
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	carmustine Sensitive: A2 - Guideline carmustine Sensitive : A2	carmustine Sensitive: A2 - Guideline carmustine Sensitive : A2
IDH1 mutation	Astrocytoma	IDH1 mutation	Astrocytoma	lomustine Sensitive: A2 - Guideline lomustine Sensitive : A2	lomustine Sensitive: A2 - Guideline lomustine Sensitive : A2
IDH1 mutation	Glioma	IDH1 mutation	Glioma	temozolomide gel Sensitive: B - Late Trials temozolomide gel Sensitive : B	temozolomide gel Sensitive: B - Late Trials temozolomide gel Sensitive : B
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	gilteritinib Resistant: B - Late Trials gilteritinib Resistant : B	gilteritinib Resistant: B - Late Trials gilteritinib Resistant : B
IDH1 mutation	Glioma	IDH1 mutation	Glioma	temozolomide Sensitive: B - Late Trials temozolomide Sensitive : B	temozolomide Sensitive: B - Late Trials temozolomide Sensitive : B
IDH1 mutation	Glioma	IDH1 mutation	Glioma	PCV Sensitive: B - Late Trials PCV Sensitive : B	PCV Sensitive: B - Late Trials PCV Sensitive : B
IDH1 mutation	Glioma	IDH1 mutation	Glioma	S95032 Sensitive: B - Late Trials S95032 Sensitive : B	S95032 Sensitive: B - Late Trials S95032 Sensitive : B
IDH1 mutation	Glioma	IDH1 mutation	Glioma	ivosidenib Sensitive: C1 - Off-label ivosidenib Sensitive : C1	ivosidenib Sensitive: C1 - Off-label ivosidenib Sensitive : C1
IDH1 mutation	Glioblastoma	IDH1 mutation	Glioblastoma	temozolomide Sensitive: C2 – Inclusion Criteria temozolomide Sensitive : C2	temozolomide Sensitive: C2 – Inclusion Criteria temozolomide Sensitive : C2
IDH1 mutation	Glioblastoma	IDH1 mutation	Glioblastoma	NEO100 Sensitive: C2 – Inclusion Criteria NEO100 Sensitive : C2	NEO100 Sensitive: C2 – Inclusion Criteria NEO100 Sensitive : C2
IDH1 mutation	Glioma	IDH1 mutation	Glioma	TG02 Sensitive: C3 – Early Trials TG02 Sensitive : C3	TG02 Sensitive: C3 – Early Trials TG02 Sensitive : C3
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	cytarabine/daunorubicin liposomal formulation Sensitive: C3 – Early Trials cytarabine / daunorubicin liposomal formulation Sensitive : C3	cytarabine/daunorubicin liposomal formulation Sensitive: C3 – Early Trials cytarabine / daunorubicin liposomal formulation Sensitive : C3
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	venetoclax + ABBV-621 Sensitive: C3 – Early Trials venetoclax + ABBV-621 Sensitive : C3	venetoclax + ABBV-621 Sensitive: C3 – Early Trials venetoclax + ABBV-621 Sensitive : C3
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	venetoclax + ivosidenib Sensitive: C3 – Early Trials venetoclax + ivosidenib Sensitive : C3	venetoclax + ivosidenib Sensitive: C3 – Early Trials venetoclax + ivosidenib Sensitive : C3
IDH1 mutation	Glioblastoma	IDH1 mutation	Glioblastoma	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3	pembrolizumab Resistant: C3 – Early Trials pembrolizumab Resistant : C3
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	CFI-400945 Sensitive: C3 – Early Trials CFI-400945 Sensitive : C3	CFI-400945 Sensitive: C3 – Early Trials CFI-400945 Sensitive : C3
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	venetoclax + midostaurin Resistant: C3 – Early Trials venetoclax + midostaurin Resistant : C3	venetoclax + midostaurin Resistant: C3 – Early Trials venetoclax + midostaurin Resistant : C3
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	venetoclax + gilteritinib Resistant: C3 – Early Trials venetoclax + gilteritinib Resistant : C3	venetoclax + gilteritinib Resistant: C3 – Early Trials venetoclax + gilteritinib Resistant : C3
IDH1 mutation	Acute Myelogenous Leukemia	IDH1 mutation	Acute Myelogenous Leukemia	venetoclax + sorafenib Resistant: C3 – Early Trials venetoclax + sorafenib Resistant : C3	venetoclax + sorafenib Resistant: C3 – Early Trials venetoclax + sorafenib Resistant : C3
IDH1 mutation	Chronic Myelomonocytic Leukemia	IDH1 mutation	Chronic Myelomonocytic Leukemia	venetoclax Sensitive: C3 – Early Trials venetoclax Sensitive : C3	venetoclax Sensitive: C3 – Early Trials venetoclax Sensitive : C3
IDH1 mutation	Glioma	IDH1 mutation	Glioma	BAY1436032 Sensitive: C3 – Early Trials BAY1436032 Sensitive : C3	BAY1436032 Sensitive: C3 – Early Trials BAY1436032 Sensitive : C3
IDH1 mutation	Anaplastic Astrocytoma	IDH1 mutation	Anaplastic Astrocytoma	PCV Sensitive: C3 – Early Trials PCV Sensitive : C3	PCV Sensitive: C3 – Early Trials PCV Sensitive : C3
IDH1 mutation	Sarcoma	IDH1 mutation	Sarcoma	olaparib Sensitive: C3 – Early Trials olaparib Sensitive : C3	olaparib Sensitive: C3 – Early Trials olaparib Sensitive : C3
IDH1 mutation	Myelodysplastic Syndrome	IDH1 mutation	Myelodysplastic Syndrome	venetoclax + ivosidenib Sensitive: C3 – Early Trials venetoclax + ivosidenib Sensitive : C3	venetoclax + ivosidenib Sensitive: C3 – Early Trials venetoclax + ivosidenib Sensitive : C3

IDH1 mutation

Associations