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GENE:

HIF1A (Hypoxia inducible factor 1, alpha subunit)

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HIF1A overexpression	HER2 Negative Breast Cancer	HIF1A overexpression	HER2 Negative Breast Cancer	albumin-bound paclitaxel Sensitive: B - Late Trials albumin-bound paclitaxel Sensitive : B	albumin-bound paclitaxel Sensitive: B - Late Trials albumin-bound paclitaxel Sensitive : B
HIF1A P582S	Colorectal Cancer	HIF1A P582S	Colorectal Cancer	bevacizumab Sensitive: C3 – Early Trials bevacizumab Sensitive : C3	bevacizumab Sensitive: C3 – Early Trials bevacizumab Sensitive : C3
HIF1A overexpression	Acute Myelogenous Leukemia	HIF1A overexpression	Acute Myelogenous Leukemia	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3
HIF1A overexpression	Myelodysplastic Syndrome	HIF1A overexpression	Myelodysplastic Syndrome	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3	azacitidine Sensitive: C3 – Early Trials azacitidine Sensitive : C3
HIF1A expression	Renal Cell Carcinoma	HIF1A expression	Renal Cell Carcinoma	sunitinib Sensitive: C3 – Early Trials sunitinib Sensitive : C3	sunitinib Sensitive: C3 – Early Trials sunitinib Sensitive : C3
HIF1A expression	Clear Cell Renal Cell Carcinoma	HIF1A expression	Clear Cell Renal Cell Carcinoma	pazopanib Resistant: C3 – Early Trials pazopanib Resistant : C3	pazopanib Resistant: C3 – Early Trials pazopanib Resistant : C3
HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	nimotuzumab Sensitive: C3 – Early Trials nimotuzumab Sensitive : C3	nimotuzumab Sensitive: C3 – Early Trials nimotuzumab Sensitive : C3
HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	HIF1A overexpression	Squamous Cell Carcinoma of Head and Neck	cisplatin Resistant: C3 – Early Trials cisplatin Resistant : C3	cisplatin Resistant: C3 – Early Trials cisplatin Resistant : C3
HIF1A overexpression	Non Small Cell Lung Cancer	HIF1A overexpression	Non Small Cell Lung Cancer	EGFR inhibitor Resistant: D – Preclinical EGFR inhibitor Resistant : D	EGFR inhibitor Resistant: D – Preclinical EGFR inhibitor Resistant : D
HIF1A-PRKCH fusion	Colorectal Cancer	HIF1A-PRKCH fusion	Colorectal Cancer	IDE196 Sensitive: D – Preclinical IDE196 Sensitive : D	IDE196 Sensitive: D – Preclinical IDE196 Sensitive : D
HIF1A underexpression	Colorectal Cancer	HIF1A underexpression	Colorectal Cancer	trifluridine/tipiracil Resistant: D – Preclinical trifluridine / tipiracil Resistant : D	trifluridine/tipiracil Resistant: D – Preclinical trifluridine / tipiracil Resistant : D
HIF1A-PRKCH fusion	Cutaneous Melanoma	HIF1A-PRKCH fusion	Cutaneous Melanoma	IDE196 Resistant: D – Preclinical IDE196 Resistant : D	IDE196 Resistant: D – Preclinical IDE196 Resistant : D