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Association details:
Biomarker:HIF1A overexpression
Cancer:Non Small Cell Lung Cancer
Drug Class:EGFR inhibitor
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
Title:

High expression of hypoxia inducible factor 1a related with acquired resistant to EGFR tyrosine kinase inhibitors in NSCLC

Published date:
01/13/2021
Excerpt:
As the treatment going on, EGFR-TKIs sensitivity rate of low HIF-1α level group was much higher than that of high level group. The high expression of HIF-1α related with the acquired resistance of the first generation EGFR-TKIs...
DOI:
10.1038/s41598-020-79801-1