^
    Back
    Association details:
    Biomarker:HIF1A underexpression
    Cancer:Colorectal Cancer
    Drug:Lonsurf (trifluridine/tipiracil) (Thymidine phosphorylase inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    AACR 2020
    Title:

    Abstract 5266: Continuous trifluridine treatment in colorectal cancer cell lines- investigating its potential

    Published date:
    05/15/2020
    Excerpt:
    Additionally, HIF1A related glycolytic mRNA was downregulated in FTD long-treated cell lines compared to that in parental cell lines. Continuous FTD long-term treated cell lines were resistant to FTD.
    DOI:
    10.1158/1538-7445.AM2020-5266