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Association details:
| Biomarker: | GNAQ mutation |
|---|---|
| Cancer: | Uveal Melanoma |
| Drug: | mirdametinib (PD-0325901) (MEK inhibitor) + sotrastaurin (AEB071) (PKC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations
Excerpt:
80% of UMs harbor mutations in the Gαq family members GNAQ and GNA11…EB071 significantly slowed the growth of tumors in an allograft model of GNAQQ209L transduced melanocytes…
DOI:
10.1038/onc.2013.418
