^
1m
Phase classification • Combination therapy • Metastases
|
gemcitabine • ganitumab (AMG 479) • conatumumab (AMG 655)
2ms
Targeting IGF-IR improves neoadjuvant chemotherapy efficacy in breast cancers with low IGFBP7 expression. (PubMed, NPJ Precis Oncol)
We report that low IGFBP7 gene expression identifies a subset of breast cancers for which the addition of ganitumab, an anti-IGF-1R monoclonal antibody, to neoadjuvant chemotherapy, substantially improved the pathological complete response rate compared to neoadjuvant chemotherapy alone...Furthermore, high IGFBP7 expression predicted increased distant metastasis risk. If our findings are confirmed, decisions to halt the development of IGF-1R targeting drugs, which were based on disappointing results of prior trials that did not use predictive biomarkers, should be reviewed.
Journal
|
IGFBP7 (Insulin Like Growth Factor Binding Protein 7)
|
IGFBP7 overexpression
|
ganitumab (AMG 479)
2ms
Phase classification • Enrollment change • Combination therapy • Metastases
|
carboplatin • paclitaxel • ganitumab (AMG 479)
3ms
QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer (clinicaltrials.gov)
P1/2, N=213, Terminated, NantCell, Inc. | Phase classification: P1b/2 --> P1/2 | Completed --> Terminated; Subjects discontinued study
Phase classification • Trial termination • Combination therapy
|
cisplatin • carboplatin • etoposide IV • ganitumab (AMG 479) • rilotumumab (AMG 102)
3ms
QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors (clinicaltrials.gov)
P1/2, N=89, Terminated, NantCell, Inc. | Phase classification: P1b/2 --> P1/2
Phase classification • Combination therapy • Metastases
|
ganitumab (AMG 479) • conatumumab (AMG 655)
4ms
Phase classification • Combination therapy • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
Vectibix (panitumumab) • ganitumab (AMG 479) • rilotumumab (AMG 102)
4ms
Palbociclib + Ganitumab In Ewing Sarcoma (clinicaltrials.gov)
P2, N=10, Terminated, Dana-Farber Cancer Institute | Completed --> Terminated; The study closed early due to discontinuation of ganitumab supply.
Trial termination
|
CDK4 (Cyclin-dependent kinase 4) • EWSR1 (EWS RNA Binding Protein 1) • IGF1 (Insulin-like growth factor 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • FUS (FUS RNA Binding Protein)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
4ms
Trial completion
|
gemcitabine • ganitumab (AMG 479)
8ms
Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma (clinicaltrials.gov)
P1, N=20, Not yet recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Dec 2025
Trial completion date • Trial primary completion date • Metastases
|
everolimus • temozolomide • doxorubicin hydrochloride • pazopanib • cyclophosphamide • ifosfamide • irinotecan • Torisel (temsirolimus) • vincristine • daunorubicin • ganitumab (AMG 479)
1year
Phase I trial of ganitumab plus dasatinib to cotarget the insulin-like growth factor 1 receptor and Src family kinase YES in rhabdomyosarcoma. (PubMed, Clin Cancer Res)
The combination of dasatinib 60 mg/m2/dose daily and ganitumab 18 mg/kg every two weeks was safe and tolerable. This combination had a disease control rate of 22% at five months.
P1 data • Journal
|
dasatinib • ganitumab (AMG 479)
over1year
Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma. (PubMed, Cancer Med)
This combination lacks adequate therapeutic activity for further study, though a subset of patients had prolonged stable disease.
P2 data • Clinical Trial,Phase II • Journal
|
IGF1 (Insulin-like growth factor 1)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
over1year
Results of TRIO-15, a multicenter, open-label, phase II study of the efficacy and safety of ganitumab in patients with recurrent platinum-sensitive ovarian cancer. (PubMed, Gynecol Oncol)
IGF1R inhibition with ganitumab was well-tolerated, however, our results do not support further study of ganitumab as a single agent in unselected OC patients.
P2 data • Clinical Trial,Phase II • Journal
|
IGF1 (Insulin-like growth factor 1) • IGF2 (Insulin-like growth factor 2)
|
ganitumab (AMG 479)
almost2years
Palbociclib + Ganitumab In Ewing Sarcoma (clinicaltrials.gov)
P2, N=10, Completed, Dana-Farber Cancer Institute | Active, not recruiting --> Completed | N=18 --> 10
Trial completion • Enrollment change
|
CDK4 (Cyclin-dependent kinase 4) • EWSR1 (EWS RNA Binding Protein 1) • IGF1 (Insulin-like growth factor 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • FUS (FUS RNA Binding Protein)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
2years
The combination of trametinib and ganitumab is effective in RAS-mutated PAX-fusion negative rhabdomyosarcoma models. (PubMed, Clin Cancer Res)
We demonstrate that combined trametinib and ganitumab is effective in a genomically diverse panel of RAS-mutated FN RMS preclinical models.
Journal
|
IGF1R (Insulin-like growth factor 1 receptor) • RAS (Rat Sarcoma Virus)
|
PTEN mutation • RAS mutation • IGF1R expression • IGF1R overexpression
|
Mekinist (trametinib) • ganitumab (AMG 479)
2years
Palbociclib + Ganitumab In Ewing Sarcoma (clinicaltrials.gov)
P2, N=18, Active, not recruiting, Dana-Farber Cancer Institute | Trial primary completion date: Aug 2022 --> Dec 2022
Trial primary completion date
|
CDK4 (Cyclin-dependent kinase 4) • EWSR1 (EWS RNA Binding Protein 1) • IGF1 (Insulin-like growth factor 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • FUS (FUS RNA Binding Protein)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
over2years
Palbociclib + Ganitumab In Ewing Sarcoma (clinicaltrials.gov)
P2, N=18, Active, not recruiting, Dana-Farber Cancer Institute | Trial completion date: Aug 2022 --> Dec 2022 | Trial primary completion date: Mar 2022 --> Aug 2022
Trial completion date • Trial primary completion date
|
CDK4 (Cyclin-dependent kinase 4) • EWSR1 (EWS RNA Binding Protein 1) • IGF1 (Insulin-like growth factor 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • FUS (FUS RNA Binding Protein)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
3years
Palbociclib + Ganitumab In Ewing Sarcoma (clinicaltrials.gov)
P2, N=18, Active, not recruiting, Dana-Farber Cancer Institute | Trial primary completion date: Oct 2021 --> Mar 2022
Clinical • Trial primary completion date
|
CDK4 (Cyclin-dependent kinase 4) • EWSR1 (EWS RNA Binding Protein 1) • IGF1 (Insulin-like growth factor 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • FUS (FUS RNA Binding Protein)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
3years
Results of TRIO-14, a phase II, multicenter, randomized, placebo-controlled trial of carboplatin-paclitaxel versus carboplatin-paclitaxel-ganitumab in newly diagnosed epithelial ovarian cancer. (PubMed, Gynecol Oncol)
Addition of ganitumab to CP chemotherapy in primary EOC did not improve PFS. Our results do not support further study of ganitumab in unselected EOC patients.
Clinical • P2 data • Journal
|
IGFBP2 (Insulin-like growth factor binding protein 2)
|
carboplatin • paclitaxel • ganitumab (AMG 479)
3years
Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer. (PubMed, NPJ Breast Cancer)
I-SPY2 is an adaptively randomized phase 2 clinical trial evaluating novel agents in combination with standard-of-care paclitaxel followed by doxorubicin and cyclophosphamide in the neoadjuvant treatment of breast cancer. None were specific predictors of response to PGM, although several signatures were associated with pCR in both arms. Any further development of anti-IGF-1R therapy will require better control of anti-IGF-1R drug-induced hyperglycemia and the development of more predictive biomarkers.
Clinical • Journal
|
HER-2 (Human epidermal growth factor receptor 2) • IGF1 (Insulin-like growth factor 1)
|
HER-2 negative • HR negative
|
paclitaxel • doxorubicin hydrochloride • ganitumab (AMG 479) • metformin
3years
Palbociclib + Ganitumab In Ewing Sarcoma (clinicaltrials.gov)
P2, N=18, Active, not recruiting, Dana-Farber Cancer Institute | Recruiting --> Active, not recruiting
Clinical • Enrollment closed
|
CDK4 (Cyclin-dependent kinase 4) • EWSR1 (EWS RNA Binding Protein 1) • IGF1 (Insulin-like growth factor 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • FUS (FUS RNA Binding Protein)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
3years
I-SPY 2: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (clinicaltrials.gov)
P2; Trial completion date: Dec 2026 --> Dec 2031 | Trial primary completion date: Dec 2025 --> Dec 2030
Trial completion date • Trial primary completion date • Clinical
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
|
ER positive • ER negative
|
TargetPrint®
|
Keytruda (pembrolizumab) • Herceptin (trastuzumab) • Lynparza (olaparib) • carboplatin • Imfinzi (durvalumab) • Nerlynx (neratinib) • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • doxorubicin hydrochloride • Talzenna (talazoparib) • Verzenio (abemaciclib) • cyclophosphamide • irinotecan • Jemperli (dostarlimab-gxly) • Tukysa (tucatinib) • letrozole • veliparib (ABT-888) • Libtayo (cemiplimab-rwlc) • MK-2206 • ganitumab (AMG 479) • amcenestrant (SAR439859) • metformin • Jivadco (trastuzumab duocarmazine) • Turalio (pexidartinib) • ganetespib (ADX-1612) • Cosela (trilaciclib) • fianlimab (REGN3767) • Oraxol (oral paclitaxel/encequidar) • ladiratuzumab vedotin (SGN-LIV1A) • nelitolimod (SD-101) • patritumab (U3-1287) • trebananib (AMG 386)
almost4years
I-SPY 2: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (clinicaltrials.gov)
P2, N=4000, Recruiting, QuantumLeap Healthcare Collaborative | Phase classification: P1 --> P2
Phase classification
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
|
ER positive • ER negative
|
MammaPrint • TargetPrint®
|
Keytruda (pembrolizumab) • Herceptin (trastuzumab) • Lynparza (olaparib) • carboplatin • Imfinzi (durvalumab) • Nerlynx (neratinib) • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • doxorubicin hydrochloride • Talzenna (talazoparib) • Verzenio (abemaciclib) • cyclophosphamide • irinotecan • Jemperli (dostarlimab-gxly) • Tukysa (tucatinib) • letrozole • veliparib (ABT-888) • Libtayo (cemiplimab-rwlc) • MK-2206 • ganitumab (AMG 479) • amcenestrant (SAR439859) • metformin • Jivadco (trastuzumab duocarmazine) • Turalio (pexidartinib) • ganetespib (ADX-1612) • Cosela (trilaciclib) • fianlimab (REGN3767) • Oraxol (oral paclitaxel/encequidar) • ladiratuzumab vedotin (SGN-LIV1A) • nelitolimod (SD-101) • patritumab (U3-1287) • trebananib (AMG 386)
almost4years
A Study of MEK162 and AMG 479 in Patients With Selected Solid Tumors (clinicaltrials.gov)
P1/2, N=77, Terminated, Pfizer | Phase classification: P2 --> P1/2
Clinical • Phase classification
|
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
|
KRAS mutation • BRAF V600
|
Mektovi (binimetinib) • ganitumab (AMG 479)
4years
I-SPY 2: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (clinicaltrials.gov)
P1, N=4000, Recruiting, QuantumLeap Healthcare Collaborative | Phase classification: P2 --> P1
Clinical • Phase classification • PARP Biomarker • PD(L)-1 Biomarker
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
|
ER positive • ER negative
|
Keytruda (pembrolizumab) • Herceptin (trastuzumab) • Lynparza (olaparib) • carboplatin • Imfinzi (durvalumab) • Nerlynx (neratinib) • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • doxorubicin hydrochloride • Talzenna (talazoparib) • irinotecan • Jemperli (dostarlimab-gxly) • Tukysa (tucatinib) • veliparib (ABT-888) • Libtayo (cemiplimab-rwlc) • MK-2206 • ganitumab (AMG 479) • metformin • Jivadco (trastuzumab duocarmazine) • Turalio (pexidartinib) • ganetespib (ADX-1612) • Cosela (trilaciclib) • fianlimab (REGN3767) • Oraxol (oral paclitaxel/encequidar) • ladiratuzumab vedotin (SGN-LIV1A) • nelitolimod (SD-101) • patritumab (U3-1287) • trebananib (AMG 386)
4years
[VIRTUAL] Biomarker analysis of paclitaxel, ganitumab, and metformin (PGM) therapy in the I-SPY2 neoadjuvant clinical trial (SABCS 2020)
PGM followed by doxorubicin/cyclophosphamide (AC) did not result in substantial increases in pCR when compared to P followed by AC. While IGF gene expression profiling associated with treatment response, they were not specific for PGM. Further, biomarker analysis and strategies to control glucose will be needed to optimize anti-IGF-1R therapies.
Clinical
|
CDH1 (Cadherin 1) • IGF1 (Insulin-like growth factor 1) • IGF2 (Insulin-like growth factor 2) • IRS2 (Insulin receptor substrate 2) • IGFBP2 (Insulin-like growth factor binding protein 2) • IR (Insulin receptor) • IGFBP3 (Insulin-like growth factor binding protein 3)
|
CDH1 expression
|
MammaPrint
|
paclitaxel • doxorubicin hydrochloride • ganitumab (AMG 479) • metformin • cyclophosphamide intravenous
4years
[VIRTUAL] Preclinical therapeutic synergy of MEK1/2 and IGF1R inhibition in RAS-driven rhabdomyosarcoma (AACR-NCI-EORTC 2020)
We demonstrate that combined trametinib and ganitumab treatment shows therapeutic synergy across a wide panel of RAS-mutated RMS preclinical models. These data support testing this combination in a phase I/II clinical trial for pediatric patients with relapsed or refractory RAS-mutated RMS.
Preclinical
|
MAP2K1 (Mitogen-activated protein kinase kinase 1)
|
Mekinist (trametinib) • ganitumab (AMG 479)
4years
[VIRTUAL] Preclinical therapeutic synergy of MEK1/2 and IGF1R inhibition in RAS-driven rhabdomyosarcoma (AACR-NCI-EORTC 2020)
We demonstrate that combined trametinib and ganitumab treatment shows therapeutic synergy across a wide panel of RAS-mutated RMS preclinical models. These data support testing this combination in a phase I/II clinical trial for pediatric patients with relapsed or refractory RAS-mutated RMS.
Preclinical
|
MAP2K1 (Mitogen-activated protein kinase kinase 1)
|
Mekinist (trametinib) • ganitumab (AMG 479)
over4years
Efficacy and Safety of Regorafenib in Combination with Chemotherapy as Second-Line Treatment in Patients with Metastatic Colorectal Cancer: A Network Meta-Analysis and Systematic Literature Review. (PubMed, Adv Ther)
Regorafenib combined with chemotherapy might be a potential alternative to conventional therapeutic options in second-line treatment of patients with metastatic colorectal cancer and could be considered as the best option for treating patients with KRAS and BRAF mutated mCRC. However future RCTs are needed to confirm these results.
Retrospective data • Journal • Combination therapy
|
KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene)
|
KRAS mutation • BRAF mutation
|
Avastin (bevacizumab) • Erbitux (cetuximab) • Vectibix (panitumumab) • Stivarga (regorafenib) • ganitumab (AMG 479) • Zaltrap (ziv-aflibercept IV) • conatumumab (AMG 655)
over4years
[VIRTUAL] A phase 2 clinical trial of palbociclib and ganitumab for relapsed/refractory Ewing sarcoma (AACR-I 2020)
ctDNA levels will be measured using next generation sequencing for quantification of ctDNA and association with response, and for identification of genomic and epigenetic markers of resistance. Enrollment began in December 2019.
Clinical • P2 data
|
IGF1 (Insulin-like growth factor 1)
|
Ibrance (palbociclib) • ganitumab (AMG 479)
over4years
Application of Machine Learning to elucidate the biology predicting response in the I SPY 2 neoadjuvant breast cancer trial (BOP 2020)
Our study involves 986 patients with pre treatment gene expression and pCR data across 10 treatment arms including inhibitors of HER2: neratinib (N), pertuzumab (P), TDM1/P; AKT (MK 2206; M); IGF1R (ganitumab); HSP90 (ganetespib); PARP/DNA repair (veliparib/carboplatin; VC); ANG 1/2 (AMG386); immune checkpoints (pembrolizumab; Pembro); and a shared control arm (Ctr). Our results suggests that hypothesis driven analysis restricted to assumed mechanisms of action of the experimental agents may be insufficient, and that exploration of possible off target effects may be needed to understand the underlying biology of response or resistance.
Clinical • PARP Biomarker • PD(L)-1 Biomarker
|
ER (Estrogen receptor) • IGF1R (Insulin-like growth factor 1 receptor) • IGF1 (Insulin-like growth factor 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
|
Keytruda (pembrolizumab) • carboplatin • Nerlynx (neratinib) • Perjeta (pertuzumab) • veliparib (ABT-888) • MK-2206 • ganitumab (AMG 479) • ganetespib (ADX-1612) • trebananib (AMG 386)
almost5years
I-SPY 2: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (clinicaltrials.gov)
P2, N=4000, Recruiting, QuantumLeap Healthcare Collaborative | N=1920 --> 4000
Clinical • Enrollment change • PARP Biomarker • PD(L)-1 Biomarker
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
|
ER positive • ER negative
|
Keytruda (pembrolizumab) • Herceptin (trastuzumab) • Lynparza (olaparib) • carboplatin • Imfinzi (durvalumab) • Nerlynx (neratinib) • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • doxorubicin hydrochloride • Talzenna (talazoparib) • irinotecan • Jemperli (dostarlimab-gxly) • Tukysa (tucatinib) • veliparib (ABT-888) • Libtayo (cemiplimab-rwlc) • MK-2206 • ganitumab (AMG 479) • metformin • Jivadco (trastuzumab duocarmazine) • Turalio (pexidartinib) • ganetespib (ADX-1612) • Cosela (trilaciclib) • fianlimab (REGN3767) • Oraxol (oral paclitaxel/encequidar) • ladiratuzumab vedotin (SGN-LIV1A) • nelitolimod (SD-101) • patritumab (U3-1287) • trebananib (AMG 386)
almost5years
I-SPY 2: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (clinicaltrials.gov)
P2, N=1920, Recruiting, QuantumLeap Healthcare Collaborative | Trial primary completion date: Dec 2020 --> Dec 2025
Clinical • Trial primary completion date • PARP Biomarker • PD(L)-1 Biomarker
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
|
ER positive • ER negative
|
Keytruda (pembrolizumab) • Herceptin (trastuzumab) • Lynparza (olaparib) • carboplatin • Imfinzi (durvalumab) • Nerlynx (neratinib) • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • doxorubicin hydrochloride • Talzenna (talazoparib) • irinotecan • Jemperli (dostarlimab-gxly) • Tukysa (tucatinib) • veliparib (ABT-888) • Libtayo (cemiplimab-rwlc) • MK-2206 • ganitumab (AMG 479) • metformin • Jivadco (trastuzumab duocarmazine) • Turalio (pexidartinib) • ganetespib (ADX-1612) • Cosela (trilaciclib) • fianlimab (REGN3767) • Oraxol (oral paclitaxel/encequidar) • ladiratuzumab vedotin (SGN-LIV1A) • nelitolimod (SD-101) • patritumab (U3-1287) • trebananib (AMG 386)
5years
Application of machine learning to elucidate the biology predicting response in the I-SPY 2 neoadjuvant breast cancer trial (SABCS 2019)
We leverage machine learning to explore the limitations of using only known mechanisms of action in predicting pCR, and the extent to which biology outside known drug action improves response prediction in the first 10 arms of the trial. Our study involves 986 patients with pre-treatment gene expression and pCR data across 10 treatment arms including inhibitors of HER2: neratinib (N), pertuzumab (P), TDM1/P; AKT (MK-2206; M); IGF1R (ganitumab); HSP90 (ganetespib); PARP/DNA repair (veliparib/carboplatin; VC); ANG1/2 (AMG386); immune checkpoints (pembrolizumab; Pembro); and a shared control arm (Ctr). Our results suggests that hypothesis driven analysis restricted to assumed mechanisms of action of the experimental agents may be insufficient, and that exploration of possible off target effects may be needed to understand the underlying biology of response or resistance.
Clinical • PARP Biomarker • PD(L)-1 Biomarker
|
ER (Estrogen receptor) • IGF1R (Insulin-like growth factor 1 receptor) • IGF1 (Insulin-like growth factor 1)
|
Keytruda (pembrolizumab) • carboplatin • Nerlynx (neratinib) • Perjeta (pertuzumab) • veliparib (ABT-888) • MK-2206 • ganitumab (AMG 479) • ganetespib (ADX-1612) • trebananib (AMG 386)
almost6years
Identifying breast cancer molecular phenotypes to predict response in a modern treatment landscape: Lessons from ~1000 patients across 10 arms of the I-SPY 2 TRIAL (SABCS 2018)
Treatments included paclitaxel alone (or with trastuzumab (H) in HER2+) or combined with investigational agents: veliparib/carboplatin (VC); neratinib; MK2206; ganitumab; ganetespib; AMG386; TDM1/pertuzumab (P); H/P; and pembrolizumab (Pembro). Molecular phenotypes reflecting proliferation, immune engagement, HER2-activation, luminal/ER-signaling, and DNA repair deficiency may provide a roadmap to guide treatment prioritization for emerging therapeutics. 
Clinical • PARP Biomarker • PD(L)-1 Biomarker
|
HER-2 (Human epidermal growth factor receptor 2)
|
Keytruda (pembrolizumab) • carboplatin • paclitaxel • Nerlynx (neratinib) • Perjeta (pertuzumab) • veliparib (ABT-888) • MK-2206 • ganitumab (AMG 479) • ganetespib (ADX-1612) • trebananib (AMG 386)