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Association details:
| Biomarker: | PTEN mutation |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | ganitumab (AMG 479) (IGF-1R inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Ganitumab (AMG 479) Inhibits IGF-II–Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy
Excerpt:
In vitro, growth inhibition varied significantly among individual ovarian cancer cell lines. IGF-II mRNA and phospho–IGF-IR protein expression were quantitatively correlated with response to ganitumab, and PTEN mutations conferred resistance to ganitumab.
DOI:
10.1158/1078-0432.CCR-13-3448
