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BIOMARKER:
FGFR3 mutation
i
Other names:
FGFR3, ACH, CD333, CEK2, JTK4, Fibroblast growth factor receptor 3
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Entrez ID:
2261
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
FGFR3 S249C (12)
FGFR3 Y373C (6)
FGFR3 G370C (3)
FGFR3 R248C (3)
FGFR3 K650 (2)
FGFR3 V555M (2)
FGFR3 Y375C (2)
FANCA mutation + FGFR3 mutation (1)
FGFR3 A393E (1)
FGFR3 G380R (1)
FGFR3 G691R (1)
FGFR3 K508M (1)
FGFR3 K650E (1)
FGFR3 L496V (1)
FGFR3 S247C (1)
FGFR3 V443L (1)
FGFR3 V443M (1)
FGFR3 rearrangement (1)
FGFR3 S249C (12)
FGFR3 Y373C (6)
FGFR3 G370C (3)
FGFR3 R248C (3)
FGFR3 K650 (2)
FGFR3 V555M (2)
FGFR3 Y375C (2)
FANCA mutation + FGFR3 mutation (1)
FGFR3 A393E (1)
FGFR3 G380R (1)
FGFR3 G691R (1)
FGFR3 K508M (1)
FGFR3 K650E (1)
FGFR3 L496V (1)
FGFR3 S247C (1)
FGFR3 V443L (1)
FGFR3 V443M (1)
FGFR3 rearrangement (1)
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Associations
News
Trials
VERI cancer hierarchy
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FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
erdafitinib
Sensitive: A1 - Approval
erdafitinib
Sensitive
:
A1
erdafitinib
Sensitive: A1 - Approval
erdafitinib
Sensitive
:
A1
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
BAY 1163877
Sensitive: B - Late Trials
BAY 1163877
Sensitive
:
B
BAY 1163877
Sensitive: B - Late Trials
BAY 1163877
Sensitive
:
B
FGFR3 mutation
Cholangiocarcinoma
FGFR3 mutation
Cholangiocarcinoma
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR3 mutation
Gastric Cancer
FGFR3 mutation
Gastric Cancer
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR3 mutation
Solid Tumor
FGFR3 mutation
Solid Tumor
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR3 mutation
Bladder Cancer
FGFR3 mutation
Bladder Cancer
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
erdafitinib
Sensitive: C1 - Off-label
erdafitinib
Sensitive
:
C1
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
pemigatinib
Sensitive: C2 – Inclusion Criteria
pemigatinib
Sensitive
:
C2
pemigatinib
Sensitive: C2 – Inclusion Criteria
pemigatinib
Sensitive
:
C2
FGFR3 mutation
Bladder Cancer
FGFR3 mutation
Bladder Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR3 mutation
Breast Cancer
FGFR3 mutation
Breast Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR3 mutation
Solid Tumor
FGFR3 mutation
Solid Tumor
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR3 mutation
Non Small Cell Lung Cancer
FGFR3 mutation
Non Small Cell Lung Cancer
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
FGFR3 mutation
Non Small Cell Lung Cancer
FGFR3 mutation
Non Small Cell Lung Cancer
nintedanib
Sensitive: C3 – Early Trials
nintedanib
Sensitive
:
C3
nintedanib
Sensitive: C3 – Early Trials
nintedanib
Sensitive
:
C3
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
B-701
Sensitive: C3 – Early Trials
B-701
Sensitive
:
C3
B-701
Sensitive: C3 – Early Trials
B-701
Sensitive
:
C3
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
enfortumab vedotin-ejfv
Resistant: C3 – Early Trials
enfortumab vedotin-ejfv
Resistant
:
C3
enfortumab vedotin-ejfv
Resistant: C3 – Early Trials
enfortumab vedotin-ejfv
Resistant
:
C3
FGFR3 mutation
Melanoma
FGFR3 mutation
Melanoma
CTLA4 inhibitor
Sensitive: C3 – Early Trials
CTLA4 inhibitor
Sensitive
:
C3
CTLA4 inhibitor
Sensitive: C3 – Early Trials
CTLA4 inhibitor
Sensitive
:
C3
FGFR3 mutation
Melanoma
FGFR3 mutation
Melanoma
PD-L1 inhibitor
Sensitive: C3 – Early Trials
PD-L1 inhibitor
Sensitive
:
C3
PD-L1 inhibitor
Sensitive: C3 – Early Trials
PD-L1 inhibitor
Sensitive
:
C3
FGFR3 mutation
Melanoma
FGFR3 mutation
Melanoma
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
FGFR3 mutation
Solid Tumor
FGFR3 mutation
Solid Tumor
CPL304110
Sensitive: D – Preclinical
CPL304110
Sensitive
:
D
CPL304110
Sensitive: D – Preclinical
CPL304110
Sensitive
:
D
FGFR3 mutation
Endometrial Cancer
FGFR3 mutation
Endometrial Cancer
infigratinib
Sensitive: D – Preclinical
infigratinib
Sensitive
:
D
infigratinib
Sensitive: D – Preclinical
infigratinib
Sensitive
:
D
FGFR3 mutation
Urothelial Cancer
FGFR3 mutation
Urothelial Cancer
dasatinib + infigratinib
Sensitive: D – Preclinical
dasatinib + infigratinib
Sensitive
:
D
dasatinib + infigratinib
Sensitive: D – Preclinical
dasatinib + infigratinib
Sensitive
:
D
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