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BIOMARKER:
FGFR1 amplification
i
Other names:
FGFR1, BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM, Fibroblast growth factor receptor 1
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Entrez ID:
2260
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
FGFR1 mutation (18)
FGFR1 rearrangement (3)
FGFR1 T141R (2)
FGFR1 A354V (1)
FGFR1 V561M (1)
FGFR1 mutation (18)
FGFR1 rearrangement (3)
FGFR1 T141R (2)
FGFR1 A354V (1)
FGFR1 V561M (1)
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VERI cancer hierarchy
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FGFR1 amplification
Hormone Receptor Positive Breast Cancer
FGFR1 amplification
Hormone Receptor Positive Breast Cancer
letrozole
Resistant: B - Late Trials
letrozole
Resistant
:
B
letrozole
Resistant: B - Late Trials
letrozole
Resistant
:
B
FGFR1 amplification
Lung Non-Small Cell Squamous Cancer
FGFR1 amplification
Lung Non-Small Cell Squamous Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
futibatinib
Sensitive: C2 – Inclusion Criteria
futibatinib
Sensitive
:
C2
FGFR1 amplification
Gastric Cancer
FGFR1 amplification
Gastric Cancer
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
FGFR1 amplification
Bladder Cancer
FGFR1 amplification
Bladder Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
infigratinib
Sensitive: C2 – Inclusion Criteria
infigratinib
Sensitive
:
C2
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
TKI258
Sensitive: C2 – Inclusion Criteria
TKI258
Sensitive
:
C2
TKI258
Sensitive: C2 – Inclusion Criteria
TKI258
Sensitive
:
C2
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
ABSK091
Sensitive: C2 – Inclusion Criteria
ABSK091
Sensitive
:
C2
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
Aromatase inhibitor
Resistant: C3 – Early Trials
Aromatase inhibitor
Resistant
:
C3
Aromatase inhibitor
Resistant: C3 – Early Trials
Aromatase inhibitor
Resistant
:
C3
FGFR1 amplification
HER2 Negative Breast Cancer
FGFR1 amplification
HER2 Negative Breast Cancer
ABSK091
Sensitive: C3 – Early Trials
ABSK091
Sensitive
:
C3
ABSK091
Sensitive: C3 – Early Trials
ABSK091
Sensitive
:
C3
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
Debio 1347
Resistant: C3 – Early Trials
Debio 1347
Resistant
:
C3
Debio 1347
Resistant: C3 – Early Trials
Debio 1347
Resistant
:
C3
FGFR1 amplification
Lung Non-Small Cell Squamous Cancer
FGFR1 amplification
Lung Non-Small Cell Squamous Cancer
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
TKI258
Sensitive: C3 – Early Trials
TKI258
Sensitive
:
C3
FGFR1 amplification
HER2 Positive Breast Cancer
FGFR1 amplification
HER2 Positive Breast Cancer
trastuzumab + pertuzumab
Sensitive: C3 – Early Trials
trastuzumab + pertuzumab
Sensitive
:
C3
trastuzumab + pertuzumab
Sensitive: C3 – Early Trials
trastuzumab + pertuzumab
Sensitive
:
C3
FGFR1 amplification
HER2 Positive Breast Cancer
FGFR1 amplification
HER2 Positive Breast Cancer
trastuzumab
Sensitive: C3 – Early Trials
trastuzumab
Sensitive
:
C3
trastuzumab
Sensitive: C3 – Early Trials
trastuzumab
Sensitive
:
C3
FGFR1 amplification
Hormone Receptor Positive Breast Cancer
FGFR1 amplification
Hormone Receptor Positive Breast Cancer
palbociclib + BAY 1163877
Sensitive: C3 – Early Trials
palbociclib + BAY 1163877
Sensitive
:
C3
palbociclib + BAY 1163877
Sensitive: C3 – Early Trials
palbociclib + BAY 1163877
Sensitive
:
C3
FGFR1 amplification
HER2 Negative Breast Cancer
FGFR1 amplification
HER2 Negative Breast Cancer
pazopanib
Sensitive: C4 – Case Studies
pazopanib
Sensitive
:
C4
pazopanib
Sensitive: C4 – Case Studies
pazopanib
Sensitive
:
C4
FGFR1 amplification
Non Small Cell Lung Cancer
FGFR1 amplification
Non Small Cell Lung Cancer
M6123
Sensitive: D – Preclinical
M6123
Sensitive
:
D
M6123
Sensitive: D – Preclinical
M6123
Sensitive
:
D
FGFR1 amplification
Estrogen Receptor Positive Breast Cancer
FGFR1 amplification
Estrogen Receptor Positive Breast Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR1 amplification
Lung Cancer
FGFR1 amplification
Lung Cancer
futibatinib
Sensitive: D – Preclinical
futibatinib
Sensitive
:
D
futibatinib
Sensitive: D – Preclinical
futibatinib
Sensitive
:
D
FGFR1 amplification
Colorectal Cancer
FGFR1 amplification
Colorectal Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR1 amplification
Small Cell Lung Cancer
FGFR1 amplification
Small Cell Lung Cancer
futibatinib + TAS-117
Sensitive: D – Preclinical
futibatinib + TAS-117
Sensitive
:
D
futibatinib + TAS-117
Sensitive: D – Preclinical
futibatinib + TAS-117
Sensitive
:
D
FGFR1 amplification
Non Small Cell Lung Cancer
FGFR1 amplification
Non Small Cell Lung Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR1 amplification
Lung Cancer
FGFR1 amplification
Lung Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR1 amplification
Lung Non-Small Cell Squamous Cancer
FGFR1 amplification
Lung Non-Small Cell Squamous Cancer
ABSK091
Sensitive: D – Preclinical
ABSK091
Sensitive
:
D
ABSK091
Sensitive: D – Preclinical
ABSK091
Sensitive
:
D
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
afimoxifene
Resistant: D – Preclinical
afimoxifene
Resistant
:
D
afimoxifene
Resistant: D – Preclinical
afimoxifene
Resistant
:
D
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
PD173074
Sensitive: D – Preclinical
PD173074
Sensitive
:
D
PD173074
Sensitive: D – Preclinical
PD173074
Sensitive
:
D
FGFR1 amplification
Gastric Cancer
FGFR1 amplification
Gastric Cancer
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
ponatinib
Sensitive: D – Preclinical
ponatinib
Sensitive
:
D
FGFR1 amplification
Breast Cancer
FGFR1 amplification
Breast Cancer
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
eFT226
Sensitive: D – Preclinical
eFT226
Sensitive
:
D
FGFR1 amplification
Lung Cancer
FGFR1 amplification
Lung Cancer
ABSK091 + NBL-001 + BI2536
Sensitive: D – Preclinical
ABSK091 + NBL-001 + BI2536
Sensitive
:
D
ABSK091 + NBL-001 + BI2536
Sensitive: D – Preclinical
ABSK091 + NBL-001 + BI2536
Sensitive
:
D
FGFR1 amplification
Lung Cancer
FGFR1 amplification
Lung Cancer
NBL-001 + BI2536
Sensitive: D – Preclinical
NBL-001 + BI2536
Sensitive
:
D
NBL-001 + BI2536
Sensitive: D – Preclinical
NBL-001 + BI2536
Sensitive
:
D
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