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    Association details:
    Biomarker:FGFR1 amplification
    Cancer:Breast Cancer
    Drug:Truseltiq (infigratinib) (FGFR inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    Go to data
    Source:
    clinicaltrials.gov
    Title:

    A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies

    Excerpt:
    Patients with histologically/cytologically confirmed advanced solid tumors with FGFR1 or FGFR2 amplification or FGFR3 mutation, for which no further effective standard anticancer treatment exists
    Trial ID:
    NCT01004224
    Evidence Level:
    Sensitive: C3 – Early Trials
    Source:
    J Clin Oncol
    Title:

    Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study

    Published date:
    01/10/2017
    Excerpt:
    Adult patients were treated with escalating dosages of BGJ398 5 to 150 mg once daily or 50 mg twice daily continuously in 28-day cycles...10 of 32 patients (31%) with breast cancer treated at ≥ 100 mg had a best response of SD. Of 26 patients with breast cancer (FGFR1/2 amplified [n = 25]; FGFR3 mutant [n = 1]) with pre- and post-treatment target lesion measurements, four (15.4%) had reduced tumor burden...
    DOI:
    10.1200/JCO.2016.67.2048
    Trial ID:
    NCT01004224