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DRUG:

Erleada (apalutamide)

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Company:

J&J

Drug class:

Androgen receptor antagonist

Related drugs:

No biomarker	Prostate Cancer	No biomarker	Prostate Cancer	apalutamide Sensitive: A1 - Approval apalutamide Sensitive : A1	apalutamide Sensitive: A1 - Approval apalutamide Sensitive : A1
AR F877L	Prostate Cancer	AR F877L	Prostate Cancer	apalutamide Resistant: C3 – Early Trials apalutamide Resistant : C3	apalutamide Resistant: C3 – Early Trials apalutamide Resistant : C3
AR T878A	Prostate Cancer	AR T878A	Prostate Cancer	apalutamide Resistant: C3 – Early Trials apalutamide Resistant : C3	apalutamide Resistant: C3 – Early Trials apalutamide Resistant : C3
PTEN expression	Prostate Cancer	PTEN expression	Prostate Cancer	leuprolide acetate + apalutamide Sensitive: C3 – Early Trials leuprolide acetate + apalutamide Sensitive : C3	leuprolide acetate + apalutamide Sensitive: C3 – Early Trials leuprolide acetate + apalutamide Sensitive : C3
PTEN deletion	Prostate Cancer	PTEN deletion	Prostate Cancer	apalutamide Sensitive: C3 – Early Trials apalutamide Sensitive : C3	apalutamide Sensitive: C3 – Early Trials apalutamide Sensitive : C3
SPOP mutation	Prostate Cancer	SPOP mutation	Prostate Cancer	enzalutamide + abiraterone acetate + apalutamide Sensitive: C3 – Early Trials enzalutamide + abiraterone acetate + apalutamide Sensitive : C3	enzalutamide + abiraterone acetate + apalutamide Sensitive: C3 – Early Trials enzalutamide + abiraterone acetate + apalutamide Sensitive : C3
ER positive	Estrogen Receptor Positive Breast Cancer	ER positive	Estrogen Receptor Positive Breast Cancer	apalutamide Sensitive: D – Preclinical apalutamide Sensitive : D	apalutamide Sensitive: D – Preclinical apalutamide Sensitive : D
AR positive	Triple Negative Breast Cancer	AR positive	Triple Negative Breast Cancer	apalutamide Sensitive: D – Preclinical apalutamide Sensitive : D	apalutamide Sensitive: D – Preclinical apalutamide Sensitive : D
PTEN deletion	Prostate Cancer	PTEN deletion	Prostate Cancer	apalutamide + AZD4635 Sensitive: D – Preclinical apalutamide + AZD4635 Sensitive : D	apalutamide + AZD4635 Sensitive: D – Preclinical apalutamide + AZD4635 Sensitive : D