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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

Published date:
11/30/2020
Excerpt:
The pre-clinical efficacy of combined treatments was evaluated in multiple patient-derived xenograft (PDX) models of TNBC….Treatment with navitoclax plus ABT-414 caused a significant reduction in tumor growth in five of seven PDXs and significant tumor regression in the highest EGFR-expressing PDX.
DOI:
10.1186/s13058-020-01374-8