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DRUG CLASS:
Bcl-xL inhibitor
DRUG CLASS:
Bcl-xL inhibitor
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News alerts, weekly reports and conference planners
Related drugs:
‹
ABT 263 (19)
APG-1252 (8)
A-1331852 (6)
APG1244 (2)
AT 101 (1)
ABBV-637 (0)
AZD0466 (0)
AZD4320 (0)
LP-118 (0)
ABBV-155 (0)
ONT-701 (0)
ABT 263 (19)
APG-1252 (8)
A-1331852 (6)
APG1244 (2)
AT 101 (1)
ABBV-637 (0)
AZD0466 (0)
AZD4320 (0)
LP-118 (0)
ABBV-155 (0)
ONT-701 (0)
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Associations
(36)
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EGFR L858R
Non Small Cell Lung Cancer
EGFR L858R
Non Small Cell Lung Cancer
osimertinib + ABT 263
Sensitive: C2 – Inclusion Criteria
osimertinib + ABT 263
Sensitive
:
C2
osimertinib + ABT 263
Sensitive: C2 – Inclusion Criteria
osimertinib + ABT 263
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
osimertinib + ABT 263
Sensitive: C2 – Inclusion Criteria
osimertinib + ABT 263
Sensitive
:
C2
osimertinib + ABT 263
Sensitive: C2 – Inclusion Criteria
osimertinib + ABT 263
Sensitive
:
C2
BRAF mutation
Melanoma
BRAF mutation
Melanoma
trametinib + dabrafenib + ABT 263
Sensitive: C2 – Inclusion Criteria
trametinib + dabrafenib + ABT 263
Sensitive
:
C2
trametinib + dabrafenib + ABT 263
Sensitive: C2 – Inclusion Criteria
trametinib + dabrafenib + ABT 263
Sensitive
:
C2
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
EGFR mutation
Non Small Cell Lung Cancer
EGFR mutation
Non Small Cell Lung Cancer
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
TP53 mutation
Acute Myelogenous Leukemia
TP53 mutation
Acute Myelogenous Leukemia
A-1331852
Sensitive: C3 – Early Trials
A-1331852
Sensitive
:
C3
A-1331852
Sensitive: C3 – Early Trials
A-1331852
Sensitive
:
C3
TP53 mutation
Acute Myelogenous Leukemia
TP53 mutation
Acute Myelogenous Leukemia
ABT 263
Sensitive: C3 – Early Trials
ABT 263
Sensitive
:
C3
ABT 263
Sensitive: C3 – Early Trials
ABT 263
Sensitive
:
C3
BCL2L1 overexpression
Non Small Cell Lung Cancer
BCL2L1 overexpression
Non Small Cell Lung Cancer
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
TP53 mutation
Non Small Cell Lung Cancer
TP53 mutation
Non Small Cell Lung Cancer
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
osimertinib + APG-1252
Sensitive: C3 – Early Trials
osimertinib + APG-1252
Sensitive
:
C3
STRN-ALK rearrangement
Mesothelioma
STRN-ALK rearrangement
Mesothelioma
ABT 263
Sensitive: D – Preclinical
ABT 263
Sensitive
:
D
ABT 263
Sensitive: D – Preclinical
ABT 263
Sensitive
:
D
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
trametinib + ABT 263
Sensitive: D – Preclinical
trametinib + ABT 263
Sensitive
:
D
trametinib + ABT 263
Sensitive: D – Preclinical
trametinib + ABT 263
Sensitive
:
D
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
APG-1252
Sensitive: D – Preclinical
APG-1252
Sensitive
:
D
APG-1252
Sensitive: D – Preclinical
APG-1252
Sensitive
:
D
EGFR C797S
Non Small Cell Lung Cancer
EGFR C797S
Non Small Cell Lung Cancer
APG-1252
Sensitive: D – Preclinical
APG-1252
Sensitive
:
D
APG-1252
Sensitive: D – Preclinical
APG-1252
Sensitive
:
D
EGFR overexpression
Triple Negative Breast Cancer
EGFR overexpression
Triple Negative Breast Cancer
ABT 263 + ABBV-321
Sensitive: D – Preclinical
ABT 263 + ABBV-321
Sensitive
:
D
ABT 263 + ABBV-321
Sensitive: D – Preclinical
ABT 263 + ABBV-321
Sensitive
:
D
EGFR overexpression
Triple Negative Breast Cancer
EGFR overexpression
Triple Negative Breast Cancer
ABT 263 + ABT-414
Sensitive: D – Preclinical
ABT 263 + ABT-414
Sensitive
:
D
ABT 263 + ABT-414
Sensitive: D – Preclinical
ABT 263 + ABT-414
Sensitive
:
D
BCL2L2 overexpression
Diffuse Large B Cell Lymphoma
BCL2L2 overexpression
Diffuse Large B Cell Lymphoma
ABT 263
Resistant: D – Preclinical
ABT 263
Resistant
:
D
ABT 263
Resistant: D – Preclinical
ABT 263
Resistant
:
D
HER-2 positive
Gastric Cancer
HER-2 positive
Gastric Cancer
lapatinib + APG-1252
Sensitive: D – Preclinical
lapatinib + APG-1252
Sensitive
:
D
lapatinib + APG-1252
Sensitive: D – Preclinical
lapatinib + APG-1252
Sensitive
:
D
BCL2L1 overexpression
Gastric Cancer
BCL2L1 overexpression
Gastric Cancer
APG-1252
Sensitive: D – Preclinical
APG-1252
Sensitive
:
D
APG-1252
Sensitive: D – Preclinical
APG-1252
Sensitive
:
D
KRAS G12D
Lung Cancer
KRAS G12D
Lung Cancer
selumetinib + ABT 263
Sensitive: D – Preclinical
selumetinib + ABT 263
Sensitive
:
D
selumetinib + ABT 263
Sensitive: D – Preclinical
selumetinib + ABT 263
Sensitive
:
D
BCL2 overexpression
Multiple Myeloma
BCL2 overexpression
Multiple Myeloma
bortezomib + A-1331852
Sensitive: D – Preclinical
bortezomib + A-1331852
Sensitive
:
D
bortezomib + A-1331852
Sensitive: D – Preclinical
bortezomib + A-1331852
Sensitive
:
D
MCL1 underexpression
Multiple Myeloma
MCL1 underexpression
Multiple Myeloma
bortezomib + A-1331852
Sensitive: D – Preclinical
bortezomib + A-1331852
Sensitive
:
D
bortezomib + A-1331852
Sensitive: D – Preclinical
bortezomib + A-1331852
Sensitive
:
D
BCL2L1 underexpression
Multiple Myeloma
BCL2L1 underexpression
Multiple Myeloma
bortezomib + A-1331852
Sensitive: D – Preclinical
bortezomib + A-1331852
Sensitive
:
D
bortezomib + A-1331852
Sensitive: D – Preclinical
bortezomib + A-1331852
Sensitive
:
D
KRAS mutation
Colorectal Cancer
KRAS mutation
Colorectal Cancer
ABT 263 + AZD8055
Sensitive: D – Preclinical
ABT 263 + AZD8055
Sensitive
:
D
ABT 263 + AZD8055
Sensitive: D – Preclinical
ABT 263 + AZD8055
Sensitive
:
D
BRAF mutation
Colorectal Cancer
BRAF mutation
Colorectal Cancer
ABT 263 + AZD8055
Sensitive: D – Preclinical
ABT 263 + AZD8055
Sensitive
:
D
ABT 263 + AZD8055
Sensitive: D – Preclinical
ABT 263 + AZD8055
Sensitive
:
D
BCL2L1 overexpression
Pancreatic Cancer
BCL2L1 overexpression
Pancreatic Cancer
ACR-368 + ABT 263
Sensitive: D – Preclinical
ACR-368 + ABT 263
Sensitive
:
D
ACR-368 + ABT 263
Sensitive: D – Preclinical
ACR-368 + ABT 263
Sensitive
:
D
CHEK1 overexpression
Pancreatic Cancer
CHEK1 overexpression
Pancreatic Cancer
ACR-368 + ABT 263
Sensitive: D – Preclinical
ACR-368 + ABT 263
Sensitive
:
D
ACR-368 + ABT 263
Sensitive: D – Preclinical
ACR-368 + ABT 263
Sensitive
:
D
BCL2 overexpression + MCL1 overexpression
Gastroesophageal Cancer
BCL2 overexpression + MCL1 overexpression
Gastroesophageal Cancer
AT 101
Sensitive: D – Preclinical
AT 101
Sensitive
:
D
AT 101
Sensitive: D – Preclinical
AT 101
Sensitive
:
D
EGFR L8585R + EGFR T790M + RBM10 G840fs*7
Lung Cancer
EGFR L8585R + EGFR T790M + RBM10 G840fs*7
Lung Cancer
osimertinib + ABT 263
Sensitive: D – Preclinical
osimertinib + ABT 263
Sensitive
:
D
osimertinib + ABT 263
Sensitive: D – Preclinical
osimertinib + ABT 263
Sensitive
:
D
EGFR L858R + RBM10 Q255*
Lung Cancer
EGFR L858R + RBM10 Q255*
Lung Cancer
osimertinib + ABT 263
Sensitive: D – Preclinical
osimertinib + ABT 263
Sensitive
:
D
osimertinib + ABT 263
Sensitive: D – Preclinical
osimertinib + ABT 263
Sensitive
:
D
MCL1 overexpression
Colorectal Cancer
MCL1 overexpression
Colorectal Cancer
APG1244 + MCL1 inhibitor
Sensitive: D – Preclinical
APG1244 + MCL1 inhibitor
Sensitive
:
D
APG1244 + MCL1 inhibitor
Sensitive: D – Preclinical
APG1244 + MCL1 inhibitor
Sensitive
:
D
MCL1 overexpression
Colorectal Cancer
MCL1 overexpression
Colorectal Cancer
APG1244
Resistant: D – Preclinical
APG1244
Resistant
:
D
APG1244
Resistant: D – Preclinical
APG1244
Resistant
:
D
BCL2 overexpression
Lung Cancer
BCL2 overexpression
Lung Cancer
gefitinib + ABT 263
Sensitive: D – Preclinical
gefitinib + ABT 263
Sensitive
:
D
gefitinib + ABT 263
Sensitive: D – Preclinical
gefitinib + ABT 263
Sensitive
:
D
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