^
Association details:
| Biomarker: | EGFR overexpression |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | dordaviprone (ONC201) (AKT inhibitor, ERK inhibitor, DRD2 antagonist, ClpP agonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Epidermal growth factor receptor expression as a molecular determinant of glioblastoma response to the dopamine receptor D2 antagonist, ONC201
Excerpt:
In this panel of DRD2 expressing lines, high EGFR expression was associated with poor response to ONC201 in vitro and in vivo.
DOI:
10.1200/JCO.2020.38
