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BIOMARKER:
CCND1 amplification
i
Other names:
CCND1, BCL1, D11S287E, PRAD1, U21B31, Cyclin D1
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Entrez ID:
595
Related biomarkers:
Expression
Mutation
Others
‹
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK positive + MYC amplification + CCND1 deletion (1)
CCND1-H (1)
CCND1 mutation + HR positive (1)
EGFR exon 19 deletion + CCND1 overexpression (1)
EGFR mutation + CCND1 expression + CDKN2A deletion (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
HR positive + CCND1 amplification (1)
ALK fusion + MYC amplification + CCND1 deletion + FGFR3 deletion (1)
ALK positive + MYC amplification + CCND1 deletion (1)
CCND1-H (1)
CCND1 mutation + HR positive (1)
EGFR exon 19 deletion + CCND1 overexpression (1)
EGFR mutation + CCND1 expression + CDKN2A deletion (1)
ER L536H + ER D538G + CCND1 amplification (1)
ER positive + ESR1 mutation + CCND1 amplification (1)
HR positive + CCND1 amplification (1)
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News
Trials
VERI cancer hierarchy
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CCND1 amplification
Melanoma
CCND1 amplification
Melanoma
sorafenib
Sensitive: B - Late Trials
sorafenib
Sensitive
:
B
sorafenib
Sensitive: B - Late Trials
sorafenib
Sensitive
:
B
CCND1 amplification
Estrogen Receptor Positive Breast Cancer
CCND1 amplification
Estrogen Receptor Positive Breast Cancer
palbociclib
Resistant: C2 – Inclusion Criteria
palbociclib
Resistant
:
C2
palbociclib
Resistant: C2 – Inclusion Criteria
palbociclib
Resistant
:
C2
CCND1 amplification
Solid Tumor
CCND1 amplification
Solid Tumor
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
CCND1 amplification
Breast Cancer
CCND1 amplification
Breast Cancer
Aromatase inhibitor
Resistant: C3 – Early Trials
Aromatase inhibitor
Resistant
:
C3
Aromatase inhibitor
Resistant: C3 – Early Trials
Aromatase inhibitor
Resistant
:
C3
CCND1 amplification
Melanoma
CCND1 amplification
Melanoma
ribociclib
Sensitive: C3 – Early Trials
ribociclib
Sensitive
:
C3
ribociclib
Sensitive: C3 – Early Trials
ribociclib
Sensitive
:
C3
CCND1 amplification
Lung Non-Small Cell Squamous Cancer
CCND1 amplification
Lung Non-Small Cell Squamous Cancer
palbociclib
Sensitive: C3 – Early Trials
palbociclib
Sensitive
:
C3
palbociclib
Sensitive: C3 – Early Trials
palbociclib
Sensitive
:
C3
CCND1 amplification
Melanoma
CCND1 amplification
Melanoma
toripalimab-tpzi
Resistant: C3 – Early Trials
toripalimab-tpzi
Resistant
:
C3
toripalimab-tpzi
Resistant: C3 – Early Trials
toripalimab-tpzi
Resistant
:
C3
CCND1 amplification
Head and Neck Cancer
CCND1 amplification
Head and Neck Cancer
cetuximab + palbociclib
Sensitive: C3 – Early Trials
cetuximab + palbociclib
Sensitive
:
C3
cetuximab + palbociclib
Sensitive: C3 – Early Trials
cetuximab + palbociclib
Sensitive
:
C3
CCND1 amplification
Squamous Cell Carcinoma of Head and Neck
CCND1 amplification
Squamous Cell Carcinoma of Head and Neck
cetuximab
Sensitive: C4 – Case Studies
cetuximab
Sensitive
:
C4
cetuximab
Sensitive: C4 – Case Studies
cetuximab
Sensitive
:
C4
CCND1 amplification
Breast Cancer
CCND1 amplification
Breast Cancer
lapatinib
Sensitive: D – Preclinical
lapatinib
Sensitive
:
D
lapatinib
Sensitive: D – Preclinical
lapatinib
Sensitive
:
D
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