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Association details:
| Biomarker: | CCND1 amplification |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | lapatinib (EGFR inhibitor, HER2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro
Excerpt:
While the majority of these genes were associated with the luminal subtype, increased RB1 and cyclin D1 as well as decreased CDKN2A (p16) were associated with sensitivity to the effects of PD 0332991 on the cell cycle and growth inhibition.
DOI:
10.1186/bcr2419
