BIOMARKER:

CCND1 amplification

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CCND1 amplification	Melanoma	CCND1 amplification	Melanoma	sorafenib Sensitive: B - Late Trials sorafenib Sensitive : B	sorafenib Sensitive: B - Late Trials sorafenib Sensitive : B
CCND1 amplification	Estrogen Receptor Positive Breast Cancer	CCND1 amplification	Estrogen Receptor Positive Breast Cancer	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3	palbociclib Resistant: C3 – Early Trials palbociclib Resistant : C3
CCND1 amplification	Solid Tumor	CCND1 amplification	Solid Tumor	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3
CCND1 amplification	Breast Cancer	CCND1 amplification	Breast Cancer	Aromatase inhibitor Resistant: C3 – Early Trials Aromatase inhibitor Resistant : C3	Aromatase inhibitor Resistant: C3 – Early Trials Aromatase inhibitor Resistant : C3
CCND1 amplification	Melanoma	CCND1 amplification	Melanoma	ribociclib Sensitive: C3 – Early Trials ribociclib Sensitive : C3	ribociclib Sensitive: C3 – Early Trials ribociclib Sensitive : C3
CCND1 amplification	Lung Non-Small Cell Squamous Cancer	CCND1 amplification	Lung Non-Small Cell Squamous Cancer	palbociclib Sensitive: C3 – Early Trials palbociclib Sensitive : C3	palbociclib Sensitive: C3 – Early Trials palbociclib Sensitive : C3
CCND1 amplification	Melanoma	CCND1 amplification	Melanoma	toripalimab Resistant: C3 – Early Trials toripalimab Resistant : C3	toripalimab Resistant: C3 – Early Trials toripalimab Resistant : C3
CCND1 amplification	Head and Neck Cancer	CCND1 amplification	Head and Neck Cancer	cetuximab + palbociclib Sensitive: C3 – Early Trials cetuximab + palbociclib Sensitive : C3	cetuximab + palbociclib Sensitive: C3 – Early Trials cetuximab + palbociclib Sensitive : C3
CCND1 amplification	Breast Cancer	CCND1 amplification	Breast Cancer	lapatinib Sensitive: D – Preclinical lapatinib Sensitive : D	lapatinib Sensitive: D – Preclinical lapatinib Sensitive : D