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DRUG:

berzosertib (M6620)

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Company:

EMD Serono, Vertex

Drug class:

ATR inhibitor

Related drugs:

ATM deletion	Colorectal Cancer	ATM deletion	Colorectal Cancer	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3
BRCA1 mutation	Ovarian Cancer	BRCA1 mutation	Ovarian Cancer	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3
TP53 mutation	Gastric Cancer	TP53 mutation	Gastric Cancer	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3
TP53 mutation	Gastroesophageal Junction Adenocarcinoma	TP53 mutation	Gastroesophageal Junction Adenocarcinoma	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3	M6620 Sensitive: C3 – Early Trials M6620 Sensitive : C3
CHEK2 mutation	Tongue Carcinoma	CHEK2 mutation	Tongue Carcinoma	ABT-888 + M6620 Sensitive: C4 – Case Studies ABT-888 + M6620 Sensitive : C4	ABT-888 + M6620 Sensitive: C4 – Case Studies ABT-888 + M6620 Sensitive : C4
ATM mutation	Breast Cancer	ATM mutation	Breast Cancer	ABT-888 + M6620 Sensitive: C4 – Case Studies ABT-888 + M6620 Sensitive : C4	ABT-888 + M6620 Sensitive: C4 – Case Studies ABT-888 + M6620 Sensitive : C4
ARID1A 548fs	Ovarian Cancer	ARID1A 548fs	Ovarian Cancer	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D
ARID1A 756fs	Ovarian Cancer	ARID1A 756fs	Ovarian Cancer	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D
ARID1A deletion	Colorectal Cancer	ARID1A deletion	Colorectal Cancer	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D
MYB-NFIB fusion	Adenoid Cystic Carcinoma	MYB-NFIB fusion	Adenoid Cystic Carcinoma	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D
SLFN11 underexpression	Small Cell Lung Cancer	SLFN11 underexpression	Small Cell Lung Cancer	M6620 + lurbinectedin Sensitive: D – Preclinical M6620 + lurbinectedin Sensitive : D	M6620 + lurbinectedin Sensitive: D – Preclinical M6620 + lurbinectedin Sensitive : D
ATR mutation	Colorectal Cancer	ATR mutation	Colorectal Cancer	M6620 + SNB-101 Sensitive: D – Preclinical M6620 + SNB-101 Sensitive : D	M6620 + SNB-101 Sensitive: D – Preclinical M6620 + SNB-101 Sensitive : D
ATR mutation	Colorectal Cancer	ATR mutation	Colorectal Cancer	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D
VHL deletion	Clear Cell Renal Cell Carcinoma	VHL deletion	Clear Cell Renal Cell Carcinoma	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D
ER positive	Estrogen Receptor Positive Breast Cancer	ER positive	Estrogen Receptor Positive Breast Cancer	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D
ERCC5 overexpression	Small Cell Lung Cancer	ERCC5 overexpression	Small Cell Lung Cancer	M6620 + lurbinectedin Sensitive: D – Preclinical M6620 + lurbinectedin Sensitive : D	M6620 + lurbinectedin Sensitive: D – Preclinical M6620 + lurbinectedin Sensitive : D
SLFN11 overexpression	Small Cell Lung Cancer	SLFN11 overexpression	Small Cell Lung Cancer	M6620 + lurbinectedin Sensitive: D – Preclinical M6620 + lurbinectedin Sensitive : D	M6620 + lurbinectedin Sensitive: D – Preclinical M6620 + lurbinectedin Sensitive : D
TP53 deletion	Acute Lymphocytic Leukemia	TP53 deletion	Acute Lymphocytic Leukemia	M6620 + BAY2402234 Sensitive: D – Preclinical M6620 + BAY2402234 Sensitive : D	M6620 + BAY2402234 Sensitive: D – Preclinical M6620 + BAY2402234 Sensitive : D
ATM deletion	Bladder Cancer	ATM deletion	Bladder Cancer	M6620 Sensitive: D – Preclinical M6620 Sensitive : D	M6620 Sensitive: D – Preclinical M6620 Sensitive : D