^
Association details:
| Biomarker: | ARID1A 548fs |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | berzosertib (M6620) (ATR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
Excerpt:
We also determined the in vivo efficacy of VX-970 in mice with established tumours derived from a tumour cell line with naturally occurring ARID1A mutations (TOV21G, ARID1A p.548fs/p.756fs). In in vitro studies, we found that the TOV21G human OCCC cell line was more sensitive to both VE-821 and VX-970 than the ARID1A wild-type OCCC cell line RMG1.
DOI:
10.1038/ncomms13837
