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    Association details:
    Biomarker:MYB-NFIB fusion
    Cancer:Adenoid Cystic Carcinoma
    Drug:berzosertib (M6620) (ATR inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Oncogenesis
    Title:

    ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma

    Published date:
    01/30/2020
    Excerpt:
    Treatment of cultured MYB-NFIB positive ACC cells (ACC 1 and ACC 2) with VX-970 generated a dose-dependent decrease in proliferation and a significant increase in apoptosis…
    DOI:
    10.1038/s41389-020-0194-3