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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

APG-2575, a clinical stage BCL-2 selective inhibitor, sensitizes estrogen receptor-positive breast cancers to standard therapies in the preclinical models

Published date:
05/15/2020
Excerpt:
In a patient-derived, tamoxifen-resistant, ER+ breast cancer xenograft model, APG-2575 plus palbociclib achieved 100% overall response rate (1/3 CR, 2/3 PR)…Taken together, we demonstrated that combining APG-2575 with tamoxifen or palbociclib therapies substantially enhances antitumor activity and overcomes tamoxifen resistance in the preclinical models of ER+ breast cancer, suggesting a novel strategy for the clinical development of BCL-2 inhibitors in ER+ breast cancers.