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BIOMARKER:
ALK mutation
i
Other names:
NBLST3, CD246, Anaplastic Lymphoma Kinase, Anaplastic Lymphoma Kinase (Ki-1), CD246 Antigen, Mutant Anaplastic Lymphoma Kinase, ALK, ALK Receptor Tyrosine Kinase, Anaplastic Lymphoma Receptor Tyrosine Kinase, ALK Tyrosine Kinase Receptor
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Entrez ID:
238
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ALK positive (74)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
ALK positive (74)
ALK negative (4)
EGFR negative + ALK negative (4)
EGFR expression + ALK positive (3)
ALK expression + PDGFRA expression (1)
ALK expression + PDGFRB expression (1)
ALK overexpression (1)
ALK positive + ROS1 positive (1)
ALK positive + YAP1 overexpression (1)
ALK positive + YES1 overexpression (1)
KRT7 positive + NKX2-1 positive + ALK overexpression (1)
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ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
ALK mutation
Lung Non-Squamous Non-Small Cell Cancer
ALK mutation
Lung Non-Squamous Non-Small Cell Cancer
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
nivolumab
Sensitive: A1 - Approval
nivolumab
Sensitive
:
A1
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ceritinib
Sensitive: A2 - Guideline
ceritinib
Sensitive
:
A2
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
lorlatinib
Sensitive: A2 - Guideline
lorlatinib
Sensitive
:
A2
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
sintilimab
Sensitive: C2 – Inclusion Criteria
sintilimab
Sensitive
:
C2
sintilimab
Sensitive: C2 – Inclusion Criteria
sintilimab
Sensitive
:
C2
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
alectinib
Sensitive: C2 – Inclusion Criteria
alectinib
Sensitive
:
C2
ALK mutation
Lung Non-Squamous Non-Small Cell Cancer
ALK mutation
Lung Non-Squamous Non-Small Cell Cancer
anlotinib
Sensitive: C2 – Inclusion Criteria
anlotinib
Sensitive
:
C2
anlotinib
Sensitive: C2 – Inclusion Criteria
anlotinib
Sensitive
:
C2
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
crizotinib
Sensitive: C2 – Inclusion Criteria
crizotinib
Sensitive
:
C2
ALK mutation
Neuroblastoma
ALK mutation
Neuroblastoma
lorlatinib
Sensitive: C2 – Inclusion Criteria
lorlatinib
Sensitive
:
C2
lorlatinib
Sensitive: C2 – Inclusion Criteria
lorlatinib
Sensitive
:
C2
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
EGFR inhibitor
Sensitive: C3 – Early Trials
EGFR inhibitor
Sensitive
:
C3
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
ALK inhibitor
Sensitive: C3 – Early Trials
ALK inhibitor
Sensitive
:
C3
ALK inhibitor
Sensitive: C3 – Early Trials
ALK inhibitor
Sensitive
:
C3
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
crizotinib + alectinib
Sensitive: C3 – Early Trials
crizotinib + alectinib
Sensitive
:
C3
crizotinib + alectinib
Sensitive: C3 – Early Trials
crizotinib + alectinib
Sensitive
:
C3
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
ALK mutation
Non Small Cell Lung Cancer
ALK mutation
Non Small Cell Lung Cancer
TGRX-326
Sensitive: C3 – Early Trials
TGRX-326
Sensitive
:
C3
TGRX-326
Sensitive: C3 – Early Trials
TGRX-326
Sensitive
:
C3
ALK mutation
Melanoma
ALK mutation
Melanoma
entrectinib
Resistant: C4 – Case Studies
entrectinib
Resistant
:
C4
entrectinib
Resistant: C4 – Case Studies
entrectinib
Resistant
:
C4
ALK mutation
Melanoma
ALK mutation
Melanoma
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
ALK mutation
Neuroblastoma
ALK mutation
Neuroblastoma
crizotinib + TNO155
Sensitive: D – Preclinical
crizotinib + TNO155
Sensitive
:
D
crizotinib + TNO155
Sensitive: D – Preclinical
crizotinib + TNO155
Sensitive
:
D
ALK mutation
Neuroblastoma
ALK mutation
Neuroblastoma
ceritinib + TNO155
Sensitive: D – Preclinical
ceritinib + TNO155
Sensitive
:
D
ceritinib + TNO155
Sensitive: D – Preclinical
ceritinib + TNO155
Sensitive
:
D
ALK mutation
Neuroblastoma
ALK mutation
Neuroblastoma
lorlatinib + TNO155
Sensitive: D – Preclinical
lorlatinib + TNO155
Sensitive
:
D
lorlatinib + TNO155
Sensitive: D – Preclinical
lorlatinib + TNO155
Sensitive
:
D
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