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GENE:

ACTA2 (Actin Alpha 2 Smooth Muscle)

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ACTA2 elevation	HER2 Positive Breast Cancer	ACTA2 elevation	HER2 Positive Breast Cancer	trastuzumab Sensitive: B - Late Trials trastuzumab Sensitive : B	trastuzumab Sensitive: B - Late Trials trastuzumab Sensitive : B
ACTA2 overexpression	HER2 Positive Breast Cancer	ACTA2 overexpression	HER2 Positive Breast Cancer	trastuzumab Resistant: C3 – Early Trials trastuzumab Resistant : C3	trastuzumab Resistant: C3 – Early Trials trastuzumab Resistant : C3
ACTA2 underexpression	Gastric Cancer	ACTA2 underexpression	Gastric Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
ACTA2 overexpression	Gastric Cancer	ACTA2 overexpression	Gastric Cancer	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3	Immunotherapy Resistant: C3 – Early Trials Immunotherapy Resistant : C3
ACTA2 overexpression	Pancreatic Adenocarcinoma	ACTA2 overexpression	Pancreatic Adenocarcinoma	cisplatin + gemcitabine + albumin-bound paclitaxel Sensitive: C3 – Early Trials cisplatin + gemcitabine + albumin-bound paclitaxel Sensitive : C3	cisplatin + gemcitabine + albumin-bound paclitaxel Sensitive: C3 – Early Trials cisplatin + gemcitabine + albumin-bound paclitaxel Sensitive : C3
KIT positive + CD34 positive + ANO1 positive + ACTA2 positive	Gastrointestinal Stromal Tumor	KIT positive + CD34 positive + ANO1 positive + ACTA2 positive	Gastrointestinal Stromal Tumor	imatinib Sensitive: C4 – Case Studies imatinib Sensitive : C4	imatinib Sensitive: C4 – Case Studies imatinib Sensitive : C4
ACTA2 underexpression	Urothelial Cancer	ACTA2 underexpression	Urothelial Cancer	PD-L1 inhibitor Sensitive: D – Preclinical PD-L1 inhibitor Sensitive : D	PD-L1 inhibitor Sensitive: D – Preclinical PD-L1 inhibitor Sensitive : D