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    Association details:
    Biomarker:ACTA2 elevation
    Cancer:HER2 Positive Breast Cancer
    Drug:Herceptin (trastuzumab) (HER2 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: B - Late Trials
    Source:
    Clin Cancer Res
    Title:

    Alpha-smooth muscle actin expression in the stroma predicts resistance to trastuzumab in patients with early-stage HER2-positive breast cancer

    Published date:
    08/31/2021
    Excerpt:
    ...to identify biomarkers besides HER2 that can help predict response to trastuzumab in HER2-positive breast cancer. In the NeoALTTO cohort, elevated levels of ACTA2 were predictive for shorter DFS in the multivariate analysis (HR, 3.21; 95% CI, 1.14-9.05; P = .027).
    DOI:
    10.1158/1078-0432.CCR-21-2103