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Association details:
| Biomarker: | ACTA2 underexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ACTA2 expression predicts survival and is associated with response to immune checkpoint inhibitors in gastric cancer
Published date:
12/12/2022
Excerpt:
Of the 108 patients treated with ICI, 56% of patients with low ACTA2 expression responded to ICI versus 25% of patients with high ACTA2 expression (p=0.004)...the patient who responded to ICI had lower tumor stromal ACTA2 expression than the 4 non-responders. Digital spatial profiling of tumor samples from 4 ICI responders and 5 ICI non-responders revealed that responders may have lower ACTA2 expression...ACTA2 expression is associated with survival and ICI response in gastric cancer patients.
DOI:
10.1158/1078-0432.CCR-22-1897
