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Oncotype DX® Colon Recurrence Score test

The Oncotype DX® Colon Cancer test is a 12 gene assay measures the expression of a panel of genes in stage II and stage III A/B colon cancer tumors to predict the risk of future recurrence. Seven cancer genes associated with recurrence-free interval: Ki-67, C-MYC, MYBL2, FAP, BGN, INHBA, GADD45B. Five reference genes (to normalize expression levels): ATP5E, PGK1, GPX1, UBB, VDAC2. It proposes an additional method for stratifying recurrence risk to assist in the adjuvant chemotherapy decision.