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our Premium Content: News alerts, weekly reports and conference plannersTEST:Oncotype DX® Colon Recurrence Score test
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Company:
Exact Sciences CorpType:
Laboratory Developed Test
Related tests:
The Oncotype DX® Colon Cancer test is a 12 gene assay measures the expression of a panel of genes in stage II and stage III A/B colon cancer tumors to predict the risk of future recurrence. Seven cancer genes associated with recurrence-free interval: Ki-67, C-MYC, MYBL2, FAP, BGN, INHBA, GADD45B. Five reference genes (to normalize expression levels): ATP5E, PGK1, GPX1, UBB, VDAC2. It proposes an additional method for stratifying recurrence risk to assist in the adjuvant chemotherapy decision.
Cancer:
Colon Cancer
Gene:
ATP5F1E (ATP Synthase F1 Subunit Epsilon), BGN (Biglycan), FAP (Fibroblast activation protein, alpha), GADD45B (Growth Arrest And DNA Damage Inducible Beta), GPX1 (Glutathione peroxidase 1), INHBA (Inhibin, beta A)
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ATP5F1E (ATP Synthase F1 Subunit Epsilon), BGN (Biglycan), FAP (Fibroblast activation protein, alpha), GADD45B (Growth Arrest And DNA Damage Inducible Beta), GPX1 (Glutathione peroxidase 1), INHBA (Inhibin, beta A), MKI67 (Marker of proliferation Ki-67), MYBL2 (MYB Proto-Oncogene Like 2), MYC (V-myc avian myelocytomatosis viral oncogene homolog), PGK1 (Phosphoglycerate Kinase 1), UBB (Ubiquitin B), VDAC1 (Voltage Dependent Anion Channel 1), VDAC2 (Voltage Dependent Anion Channel 2)
Method:
RT-PCR
Confirmatory trial(s)
Confirmatory trial(s)