TEST:

Epi-TOP MPP Assay Panel

Epi-TOP MPP (Multidrug Prognosis & Prediction) Assay Panel is an in vitro diagnostic medical device that helps in genetic differential diagnosis to improve treatment efficiency through prognosis/prediction of response to immunotherapy and drug anticancer treatment based on DNA methylation biomarkers specific to each type of refractory cancer. Seesun Biomaterials' Epi-TOP technology is the world's first technology that enables direct gene amplification without the sample pretreatment step using chemicals such as bisufite, which is essential for DNA methylation testing, and is a groundbreaking technology that can analyze methylation easily and accurately by incorporating real-time polymerase chain reaction (Real-time PCR), a universal molecular diagnostic method. Epi-TOP selectively inhibits gene amplification by using its self-developed "Epi-sPNA" probe to selectively bind to the target gene, enabling the specific selection of only methylated genes. In addition, by comparing the Tm and Ct values ​​of unmethylated genes, it is possible to measure the presence and ratio of gene methylation.