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    TEST:
    EasyPGX® ready MSI

    Company:
    Diatech Pharmacogenetics
    Type:
    CE Marked
    Details
    Evidence

    News

    12ms
    MSI analysis in patients with GIST with Lynch syndrome. (ASCO 2023)
    For the first time we observed in Lynch Syndrome MSH2 mutated, simolutaneous GIST and colon cancer in the same site of ileum and PCR analisys detected a rare exemple of microsatellite instability in GIST.
    Clinical • MSi-H Biomarker
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    BRAF (B-raf proto-oncogene) • MSI (Microsatellite instability) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • PMS2 (PMS1 protein homolog 2) • NTRK (Neurotrophic receptor tyrosine kinase)
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    MSI-H/dMMR • NTRK2 fusion • KIT mutation • BRAF wild-type • KIT exon 11 mutation • MSH2 mutation • PDGFR wild-type
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    EasyPGX® ready MSI
    over1year
    Critical aspects of MSI testing in endometrial cancer: a comparison study. (PubMed, Hum Pathol)
    "Otherwise, HRM approaches and microcapillary electrophoresis platform failed to detect MSI-ECs showing minimal microsatellite shifts. In conclusion, whereas in colorectal site several technologies are eligible for MSI test, in ECs MSI test should be based on fluorescent capillary electrophoresis as it identifies a higher proportion of cases that could be misdiagnosed with other strategies."
    Journal
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    MSI (Microsatellite instability)
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    MSI-H/dMMR
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    EasyPGX® ready MSI • Idylla™ MSI Test • OncoMate™ MSI