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DRUG:

YH001

i
Other names: YH001, YH-001
Associations
Company:
Biocytogen, Tracon Pharma
Drug class:
CTLA4 inhibitor
Associations
over1year
A Study to Evaluate YH001 in Combination With Toripalimab in Subjects With Advanced NSCLC and HCC (clinicaltrials.gov)
P2, N=0, Withdrawn, Eucure (Beijing) Biopharma Co., Ltd | N=80 --> 0 | Not yet recruiting --> Withdrawn
Enrollment change • Trial withdrawal • Combination therapy • Metastases
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PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
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Loqtorzi (toripalimab-tpzi) • YH001
almost2years
A Study to Evaluate YH001 in Combination With Toripalimab in Subjects With Advanced NSCLC and HCC (clinicaltrials.gov)
P2, N=80, Not yet recruiting, Eucure (Beijing) Biopharma Co., Ltd | Trial completion date: Jun 2023 --> Mar 2025 | Initiation date: Dec 2022 --> Jun 2023 | Trial primary completion date: Dec 2022 --> Dec 2024
Trial completion date • Trial initiation date • Trial primary completion date • Combination therapy • Metastases
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PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
|
Loqtorzi (toripalimab-tpzi) • YH001
over2years
A Study to Evaluate YH001 in Combination With Toripalimab in Subjects With Advanced NSCLC and HCC (clinicaltrials.gov)
P2, N=80, Not yet recruiting, Eucure (Beijing) Biopharma Co., Ltd | Initiation date: Mar 2022 --> Dec 2022
Trial initiation date • Combination therapy
|
PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
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Loqtorzi (toripalimab-tpzi) • YH001
almost3years
New P2 trial • Combination therapy
|
PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
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Loqtorzi (toripalimab-tpzi) • YH001
over4years
[VIRTUAL] A novel anti-CTLA-4 antibody with potent anti-tumor activity emerged using humanized CTLA-4 mouse model (AACR-II 2020)
Ipilimumab, a fully human IgG1 monoclonal antibody, is the only commercially available CTLA-4 antagonist. YH001 showed dose-dependent in vivo anti-cancer efficacy, as well as Treg depletion and increased CD8+/Treg ratio in human CTLA-4 knock-in mice bearing MC38 tumors.Exposure to YH001 was dose proportional with a half-life of approximately 5 days in cynomolgus monkey. Our preclinical investigation of YH001 demonstrates Biocytogen’s capability in discovering clinical candidates using its robust antibody discovery platform.
Preclinical • IO biomarker
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IFNG (Interferon, gamma) • IL2 (Interleukin 2)
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CTLA4 expression
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Yervoy (ipilimumab) • YH001