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DRUG:
vilastobart (XTX101)
i
Other names:
XTX101, XTX 101, XTX-101
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News alerts, weekly reports and conference planners
Associations
(1)
News
Trials
Company:
Xilio Therap
Drug class:
CTLA4 inhibitor
Related drugs:
‹
ipilimumab (223)
tremelimumab (60)
KN046 (19)
cadonilimab (10)
iparomlimab/tuvonralimab (3)
ipilimumab biosimilar (CS1002) (2)
MK-1308 (2)
GI-101 (1)
BNT316 (1)
MEDI5752 (1)
XmAb717 (1)
AI-061 (0)
ATOR-1015 (0)
BMS-986218 (0)
BMS-986249 (0)
BMS-986288 (0)
BT-001 (0)
CD200AR-L (0)
CTLA4 inhibitor (0)
IBI310 (ipilimumab biosimilar) (0)
INV322 (0)
KD6001 (0)
MT-8421 (0)
prolgolimab/nurulimab (0)
ONCR-177 (0)
PF-06753512 (0)
RP2 (0)
RP3 (0)
SAL008 (0)
SHR-8068 (0)
SYN-27M (0)
TG6050 (0)
YH001 (0)
XmAb22841 (0)
SI-B003 (0)
MGD019 (0)
ADG126 (0)
HBM4003 (0)
MK-1308A (0)
ipilimumab (223)
tremelimumab (60)
KN046 (19)
cadonilimab (10)
iparomlimab/tuvonralimab (3)
ipilimumab biosimilar (CS1002) (2)
MK-1308 (2)
GI-101 (1)
BNT316 (1)
MEDI5752 (1)
XmAb717 (1)
AI-061 (0)
ATOR-1015 (0)
BMS-986218 (0)
BMS-986249 (0)
BMS-986288 (0)
BT-001 (0)
CD200AR-L (0)
CTLA4 inhibitor (0)
IBI310 (ipilimumab biosimilar) (0)
INV322 (0)
KD6001 (0)
MT-8421 (0)
prolgolimab/nurulimab (0)
ONCR-177 (0)
PF-06753512 (0)
RP2 (0)
RP3 (0)
SAL008 (0)
SHR-8068 (0)
SYN-27M (0)
TG6050 (0)
YH001 (0)
XmAb22841 (0)
SI-B003 (0)
MGD019 (0)
ADG126 (0)
HBM4003 (0)
MK-1308A (0)
›
Associations
(1)
News
Trials
Filter by
Latest
4ms
Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=136, Recruiting, Xilio Development, Inc. | N=96 --> 136
4 months ago
Enrollment change • Combination therapy • Metastases
|
Tecentriq (atezolizumab) • vilastobart (XTX101)
10ms
XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. (PubMed, J Immunother Cancer)
These data demonstrate that XTX101 retains the full potency of an Fc-enhanced CTLA-4 antagonist within the TME while minimizing the activity in non-tumor tissue, supporting the further evaluation of XTX101 in clinical studies.
10 months ago
PK/PD data • Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
|
CD8 (cluster of differentiation 8)
|
Yervoy (ipilimumab) • vilastobart (XTX101)
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