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    BIOMARKER:

    XPA expression

    i
    Other names: XPAC, Xeroderma Pigmentosum Group A-Complementing Protein, Xeroderma Pigmentosum, Complementation Group A, DNA Repair Protein Complementing XP-A Cells, XP1
    Entrez ID:
    7507
    Related biomarkers:
    Expression
    3ms
    Prognostic value of nucleotide excision repair and translesion DNA synthesis proteins in muscle-infiltrating bladder carcinoma. (PubMed, BMC Cancer)
    Our study showed significant correlations between the tumor expression of XPG and POLI, as well as NER and TLS as the whole pathways, and inferior OS. Hence, they could constitute prognostic biomarkers and potentially promising therapeutic targets in MIBC. However, a prospective trial is required for further validation, thereby overcoming the limitations of this study.
    Journal
    |
    ERCC1 (Excision repair cross-complementation group 1) • XPA (XPA, DNA Damage Recognition And Repair Factor) • REV3L (REV3 Like DNA Directed Polymerase Zeta Catalytic Subunit)
    |
    XPA expression
    |
    cisplatin • gemcitabine
    11ms
    DNA Repair Activity in the Skin of Day and Night Shift Workers (clinicaltrials.gov)
    P=N/A, N=48, Recruiting, Wright State University | Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2025
    Trial completion date • Trial primary completion date
    |
    CHEK1 (Checkpoint kinase 1) • XPA (XPA, DNA Damage Recognition And Repair Factor) • CLOCK (Clock Circadian Regulator)
    |
    XPA expression
    2years
    Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. (PubMed, Cell Death Dis)
    Consistently, XPA knockout sensitized prostate cancer cells to abiraterone and enzalutamide treatment. In conclusion, IDA combats abiraterone and enzalutamide resistance by reducing XPA protein level in prostate cancer.
    Journal
    |
    XPA (XPA, DNA Damage Recognition And Repair Factor)
    |
    XPA expression
    |
    Xtandi (enzalutamide) • abiraterone acetate • idarubicin hydrochloride
    over3years
    XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner. (PubMed, J Gastrointest Oncol)
    XPA overexpression was found to suppress HCC by inducing autophagy and apoptosis and repressing EMT and proliferation. Each of these effects may be involved in modulating the PI3K/Akt/mTOR signaling pathway.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • VIM (Vimentin) • XPA (XPA, DNA Damage Recognition And Repair Factor) • BECN1 (Beclin 1)
    |
    BCL2 expression • BAX expression • VIM expression • XPA expression • XPA overexpression
    over3years
    DNA Repair Protein Expression and Oxidative/Nitrosative Stress in Ulcerative Colitis and Sporadic Colorectal Cancer. (PubMed, Anticancer Res)
    Oxidative/nitrosative stress is prevalent in the colon of both diseases. Nucleotide excision repair and non-homologous end-joining double-strand break repair may be compromised in colorectal cancer, but not in ulcerative colitis.
    Journal • PARP Biomarker
    |
    MLH1 (MutL homolog 1) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • XPA (XPA, DNA Damage Recognition And Repair Factor)
    |
    XPA expression
    over3years
    Impact of Neoantigen Expression and T-Cell Activation on Breast Cancer Survival. (PubMed, Cancers (Basel))
    In contrast, there was no significant difference in the T-cell activation and PR negative subgroups. In conclusion, neoantigens may serve as immunogenic agents for immunotherapy in breast cancer.
    Journal • Tumor Mutational Burden • BRCA Biomarker • IO biomarker
    |
    PGR (Progesterone receptor) • TMB (Tumor Mutational Burden) • BRCA2 (Breast cancer 2, early onset) • MSH2 (MutS Homolog 2) • ERCC1 (Excision repair cross-complementation group 1) • CHEK2 (Checkpoint kinase 2) • RAD51 (RAD51 Homolog A) • CHEK1 (Checkpoint kinase 1) • XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) • XRCC2 (X-Ray Repair Cross Complementing 2) • XPA (XPA, DNA Damage Recognition And Repair Factor)
    |
    BLM mutation • BRCA2 expression • PGR negative • XPA expression
    over3years
    Usefulness of PET-guided surgery with 64Cu-labeled cetuximab for resection of intrapancreatic residual tumors in a xenograft mouse model of resectable pancreatic cancer. (PubMed, Nucl Med Commun)
    OpenPET-guided surgery with 64Cu-labeled-cetuximab enabled intraoperative identification and resection of intrapancreatic small residual tumors. This technology could be useful to prevent tumor residuals during surgery and improve pancreatic cancer survival.
    Preclinical • Journal
    |
    EGFR (Epidermal growth factor receptor)
    |
    XPA expression
    |
    Erbitux (cetuximab)