News - XPA expression

4ms

DNA Repair Activity in the Skin of Day and Night Shift Workers (clinicaltrials.gov)

P=N/A, N=48, Recruiting, Wright State University | Trial completion date: Dec 2023 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2025

4 months ago

Trial completion date • Trial primary completion date

CHEK1 (Checkpoint kinase 1) • XPA (XPA, DNA Damage Recognition And Repair Factor) • CLOCK (Clock Circadian Regulator)

XPA expression

over1year

Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. (PubMed, Cell Death Dis)

Consistently, XPA knockout sensitized prostate cancer cells to abiraterone and enzalutamide treatment. In conclusion, IDA combats abiraterone and enzalutamide resistance by reducing XPA protein level in prostate cancer.

over 1 year ago

Journal

XPA (XPA, DNA Damage Recognition And Repair Factor)

XPA expression

Xtandi (enzalutamide capsule) • abiraterone acetate • idarubicin hydrochloride

over2years

XPA serves as an autophagy and apoptosis inducer by suppressing hepatocellular carcinoma in a PI3K/Akt/mTOR dependent manner. (PubMed, J Gastrointest Oncol)

XPA overexpression was found to suppress HCC by inducing autophagy and apoptosis and repressing EMT and proliferation. Each of these effects may be involved in modulating the PI3K/Akt/mTOR signaling pathway.

over 2 years ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • VIM (Vimentin) • XPA (XPA, DNA Damage Recognition And Repair Factor) • BECN1 (Beclin 1)

BCL2 expression • BAX expression • VIM expression • XPA expression • XPA overexpression

almost3years

DNA Repair Protein Expression and Oxidative/Nitrosative Stress in Ulcerative Colitis and Sporadic Colorectal Cancer. (PubMed, Anticancer Res)

Oxidative/nitrosative stress is prevalent in the colon of both diseases. Nucleotide excision repair and non-homologous end-joining double-strand break repair may be compromised in colorectal cancer, but not in ulcerative colitis.

almost 3 years ago

Journal • PARP Biomarker

MLH1 (MutL homolog 1) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • XPA (XPA, DNA Damage Recognition And Repair Factor)

XPA expression

almost3years

Impact of Neoantigen Expression and T-Cell Activation on Breast Cancer Survival. (PubMed, Cancers (Basel))

In contrast, there was no significant difference in the T-cell activation and PR negative subgroups. In conclusion, neoantigens may serve as immunogenic agents for immunotherapy in breast cancer.

almost 3 years ago

Journal • Tumor Mutational Burden • BRCA Biomarker • IO biomarker

PGR (Progesterone receptor) • TMB (Tumor Mutational Burden) • BRCA2 (Breast cancer 2, early onset) • MSH2 (MutS Homolog 2) • ERCC1 (Excision repair cross-complementation group 1) • CHEK2 (Checkpoint kinase 2) • RAD51 (RAD51 Homolog A) • CHEK1 (Checkpoint kinase 1) • XPC (XPC Complex Subunit, DNA Damage Recognition And Repair Factor) • XRCC2 (X-Ray Repair Cross Complementing 2) • XPA (XPA, DNA Damage Recognition And Repair Factor)

BLM mutation • BRCA2 expression • PGR negative • XPA expression

almost3years

Usefulness of PET-guided surgery with 64Cu-labeled cetuximab for resection of intrapancreatic residual tumors in a xenograft mouse model of resectable pancreatic cancer. (PubMed, Nucl Med Commun)

OpenPET-guided surgery with 64Cu-labeled-cetuximab enabled intraoperative identification and resection of intrapancreatic small residual tumors. This technology could be useful to prevent tumor residuals during surgery and improve pancreatic cancer survival.

almost 3 years ago

Preclinical • Journal

EGFR (Epidermal growth factor receptor)

XPA expression

Erbitux (cetuximab)