^
10d
YAP regulates HER3 signaling-driven adaptive resistance to RET inhibitors in RET-aberrant cancer. (PubMed, Clin Cancer Res)
The YAP-HER3 axis is crucial for the survival and adaptive resistance of high YAP-expressing RET-aberrant cancer cells treated with RET-TKIs. Combining YAP/HER3 inhibition with RET-TKIs represents a highly potent strategy for initial treatment.
Journal
|
RET (Ret Proto-Oncogene) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3)
|
RET fusion • ERBB3 expression • RET expression • RET positive
|
Gilotrif (afatinib) • Retevmo (selpercatinib) • Gavreto (pralsetinib) • Visudyne (verteporfin)
24d
Panax Notoginseng Saponins promotes the meningeal lymphatic system-mediated hematoma absorption in intracerebral hemorrhage. (PubMed, Phytomedicine)
PNS might be effective for ICH treatment by enhancing lymphangiogenesis and the meningeal lymphatic drainage function, thereby attenuating inflammation and promoting neurological recovery. The role of PNS in regulation of MLVs was investigated for the first time. This study provides a novel insight for PNS in the medical therapy of ICH.
Journal
|
TNFA (Tumor Necrosis Factor-Alpha)
|
Visudyne (verteporfin)
1m
Drug repositioning identifies potential autophagy inhibitors for the LIR motif p62/SQSTM1 protein. (PubMed, Comput Biol Chem)
The results revealed that the kanamycin, velpatasvir, verteporfin, and temoporfin significantly decreased the binding of LIR to the p62 protein. Finally, we experimentally confirmed that Kanamycin can inhibit autophagy-associated acidic vesicular formation in breast cancer MCF-7 and MDA-MB 231 cells. These repositioned drugs may represent novel autophagy modulators in clinical management, warranting further investigation.
Journal
|
SQSTM1 (Sequestosome 1)
|
Visudyne (verteporfin) • Foscan (temoporfin)
2ms
RNA sequencing identifies lung cancer lineage and facilitates drug repositioning. (PubMed, PeerJ)
Our results indicated that dinaciclib and alvocidib exhibited similar activity and sensitivity in the neuroendocrine cluster. Also, a lineage factor named KLF5 recognized by inferred transcriptional factors activity could be suppressed by verteporfin.
Journal • IO biomarker
|
STK11 (Serine/threonine kinase 11)
|
STK11 mutation
|
Visudyne (verteporfin) • alvocidib (DSP-2033) • dinaciclib (MK-7965)
2ms
Enrollment open • Enrollment change
|
Visudyne (verteporfin)
3ms
IL-32 aggravates metabolic disturbance in human nucleus pulposus cells by activating FAT4-mediated Hippo/YAP signaling. (PubMed, Int Immunopharmacol)
Lentivirus overexpressing IL-32 or knocking down Fat atypical cadherin 4 (FAT4), yes-associated protein (YAP) inhibitor-Verteporfin (VP) were used to treat human NP cells, to explore the pathogenesis of IL-32...Mechanistically, the elevation of IL-32 in the inflammatory microenvironment enhanced its interactions with FAT4 and mammalian sterile 20-like kinase1/2 (MST1/2) proteins, prompting MST1/2 phosphorylation, and activating the Hippo/YAP signaling pathway, causing matrix metabolism disorder in NP cells. Our results suggest that IL-32 mediates matrix metabolism disorders in NP cells in the inflammatory micro-environment via the FAT4/MST/YAP axis, providing a theoretical basis for the precise treatment of IDD.
Journal
|
TNFA (Tumor Necrosis Factor-Alpha) • FAT4 (FAT Atypical Cadherin 4) • IL32 (Interleukin 32)
|
Visudyne (verteporfin)
3ms
Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer (clinicaltrials.gov)
P2, N=25, Not yet recruiting, Mayo Clinic | Trial completion date: Jul 2029 --> Oct 2029 | Initiation date: Jun 2024 --> Oct 2024 | Trial primary completion date: Jul 2029 --> Oct 2029
Trial completion date • Trial initiation date • Trial primary completion date • Metastases
|
Keytruda (pembrolizumab) • oxaliplatin • irinotecan • leucovorin calcium • Visudyne (verteporfin) • fluorouracil topical
4ms
Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module. (PubMed, Acta Pharmacol Sin)
Through the GDSC database, we found that CEMIP expression levels were positively correlated with the IC50 values of several commonly used chemotherapeutic drugs in SCLC cells (cisplatin, gemcitabine, 5-fluorouracil and cyclophosphamide). The combination of the SRC inhibitor dasatinib or the YAP inhibitor verteporfin and cisplatin/etoposide (EP regimen) displayed excellent synergistic antitumor effects on SCLC both in vitro and in vivo. This study demonstrated that targeted therapy against the CEMIP/SRC/YAP complex is a potential strategy for SCLC and provides a rationale for the development of future clinical trials with translational prospects.
Journal
|
CEMIP (Cell Migration Inducing Hyaluronidase 1)
|
cisplatin • dasatinib • gemcitabine • 5-fluorouracil • cyclophosphamide • etoposide IV • Visudyne (verteporfin)
5ms
A Physiochemical, In Vitro, and In Vivo Comparative Analysis of Verteporfin-Lipid Conjugate Formulations: Solid Lipid Nanoparticles and Liposomes. (PubMed, ACS Appl Bio Mater)
In this study, we prepared 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)-based solid lipid nanoparticles (LNPs) that stably entrap BPD-PC, which resemble the composition of the SpikevaxⓇ Moderna COVID-19 vaccine, and compared them to a DPPC based liposomal formulation (Lipo BPD-PC). In vivo studies revealed that CT1BA5 tumor fluorescence signals from BPD-PC were 2.41-fold higher with Lipo BPD-PC than with LNP BPD-PC; however, no significant difference was observed in tumor tissue selectivity or tumor penetration. As such, we present LNP BPD-PC as a unique and more stable nanoplatform to carry BPD lipid conjugates, such as BPD-PC, with a potential for future photodynamic immune priming studies and multiagent drug delivery.
Preclinical • Journal • Lipid Nanoparticle
|
CALR (Calreticulin)
|
Visudyne (verteporfin)
5ms
IQGAP1 overexpression attenuates chemosensitivity through YAP-mediated ferroptosis inhibition in esophageal squamous cell cancer cells. (PubMed, Arch Biochem Biophys)
However, the underlying effect and molecular mechanisms of IQGAP1 on paclitaxel (PTX) resistance and ferroptosis in ESCC remain to be elucidated...Importantly, reductions of chemosensitivity and ferroptosis caused by IQGAP1 overexpression were reversed with ferroptosis inducer RSL3, while the increases of chemosensitivity and ferroptosis caused by IQGAP1 knockdown were reversed with ferroptosis inhibitor ferrostatin-1 (Fer-1) in ESCC cells, indicating that IQGAP1 played a key role in resistance to PTX through regulating ferroptosis...YAP inhibitor Verteporfin (VP) could reverse the effects of IQGAP1 overexpression on ESCC chemoresistance and ferroptosis. Taken together, our findings suggest that IQGAP1 promotes chemoresistance by blocking ferroptosis through targeting YAP. IQGAP1 may be a novel therapeutic target for overcoming chemoresistance in ESCC.
Journal
|
IQGAP1 (IQ Motif Containing GTPase Activating Protein 1)
|
paclitaxel • Visudyne (verteporfin) • RSL3
6ms
The role of yes activated protein (YAP) in melanoma metastasis. (PubMed, iScience)
YAP activates the expression of the matricellular proteins CCN1 (cyr61) and CCN2 (ctgf), themselves mediators of fibrogenesis and oncogenesis, and coordination of matrix deposition and angiogenesis. This review discusses how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.
Review • Journal
|
CCN1 (Cellular Communication Network Factor 1) • CTGF (Connective tissue growth factor)
|
Visudyne (verteporfin)
6ms
Dysfunctional adipocytes promote tumor progression through YAP/TAZ-dependent cancer-associated adipocyte transformation. (PubMed, Nat Commun)
Treatment with the YAP/TAZ inhibitor, verteporfin, suppresses tumor progression in BaKO and HFD-fed mice, highlighting its efficacy against mice with metabolic dysregulation. Overall, our findings provide insights into the key mediators of CAA and their significance in developing a TME, thereby suggesting a viable approach targeting adipocyte homeostasis to suppress cancer growth.
Journal
|
BECN1 (Beclin 1) • TAFAZZIN (Tafazzin)
|
Visudyne (verteporfin)
6ms
The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells. (PubMed, BMC Cancer)
Accordingly, Verteporfin and CA3, two drugs affecting the activity of YAP and TAZ, showed antagonistic effects with oxaliplatin in co-treatments. Importantly, using several colorectal cell lines, we show that the sensitizing action of TAZ to oxaliplatin is dependent on the p53 status of the cells. Our results support thus an early action of TAZ to sensitize cells to oxaliplatin, consistent with a model in which nuclear TAZ in the context of DNA damage and p53 activity pushes cells towards apoptosis.
Journal
|
TP53 (Tumor protein P53) • WWTR1 (WW Domain Containing Transcription Regulator 1)
|
oxaliplatin • Visudyne (verteporfin)
6ms
Verteporfin suppressed mitophagy via PINK1/parkin pathway in endometrial cancer. (PubMed, Am J Cancer Res)
This suggests that verteporfin may inhibit mitophagy by elevating ROS levels, thereby inhibiting EC cell viability. The effect of verteporfin on mitophagy supports further investigation as a potential therapeutic option for EC.
Journal
|
PINK1 (PTEN Induced Kinase 1)
|
Visudyne (verteporfin)
6ms
Interstitial Photodynamic Therapy Following Palliative Radiotherapy in Treating Patients With Inoperable Malignant Central Airway Obstruction (clinicaltrials.gov)
P1/2, N=39, Not yet recruiting, Roswell Park Cancer Institute | Trial completion date: Apr 2029 --> Jul 2029 | Initiation date: Apr 2024 --> Jul 2024 | Trial primary completion date: Apr 2029 --> Jul 2029
Trial completion date • Trial initiation date • Trial primary completion date
|
Visudyne (verteporfin)
7ms
Verteporfin inhibits TGF-β signaling by disrupting the Smad2/3-Smad4 interaction. (PubMed, Mol Biol Cell)
Furthermore, VP exhibited inhibitory effects on TGF-β-induced epithelial-mesenchymal transition and cell migration. Our findings indicate a novel approach to develop protein-protein interaction inhibitors of the canonical TGF-β signaling pathway for treatments of related diseases.
Journal
|
SMAD4 (SMAD family member 4) • TGFB1 (Transforming Growth Factor Beta 1) • SMAD2 (SMAD Family Member 2)
|
Visudyne (verteporfin)
7ms
New P2 trial • Metastases
|
Keytruda (pembrolizumab) • oxaliplatin • irinotecan • leucovorin calcium • Visudyne (verteporfin) • fluorouracil topical
7ms
Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells. (PubMed, Cell Signal)
Inhibiting YAP pathway either by addition of verteporfin, an inhibitor of YAP/TAZ-TEAD, or by transfection of si-RNAs targeting YAP or TAZ further enhances silibinin-induced cell damage. While enhancing YAP activity by silencing LATS1/2 or overexpressing YAPS127/397A, an active form of YAP, attenuates silibinin-induced cell damage. These findings demonstrate that inhibition of the YAP/TAZ pathway contributes to cytotoxicity of silibinin in breast cancers, shedding lights on YAP/TAZ-targeted cancer therapies.
Journal
|
YAP1 (Yes associated protein 1) • ACVR1 (Activin A Receptor Type 1) • LATS1 (Large Tumor Suppressor Kinase 1) • SOD2 (Superoxide Dismutase 2) • TAFAZZIN (Tafazzin)
|
Visudyne (verteporfin) • Undisclosed YAP/TAZ-TEAD inhibitor
7ms
Comparing Intravitreal Aflibercept Monotherapy vs Aflibercept Combined With Reduced Fluence PDT in PCV Treatment (clinicaltrials.gov)
P=N/A, N=60, Active, not recruiting, Singapore National Eye Centre | Recruiting --> Active, not recruiting | N=160 --> 60
Enrollment closed • Enrollment change
|
Visudyne (verteporfin) • Eylea (aflibercept intravitreal)
7ms
INHBA regulates Hippo signaling to confer 5-FU chemoresistance mediated by cellular senescence in colon cancer cells. (PubMed, Int J Biochem Cell Biol)
Colon cancer has become a global public health challenge, and 5-Fluorouracil (5-FU) chemoresistance is a major obstacle in its treatment. Analysis of whether to use the pathway inhibitor Verteporfin proved that INHBA facilitated colon cancer cell senescence and enhanced 5-FU chemoresistance via inactivation of Hippo signaling pathway, and consistent results were obtained in vivo. Collectively, INHBA conferred 5-FU chemoresistance mediated by cellular senescence in colon cancer cells through negative regulation of Hippo signaling.
Journal
|
IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • MMP1 (Matrix metallopeptidase 1)
|
5-fluorouracil • Visudyne (verteporfin)
7ms
Amelioration of NAFLD by sleeve gastrectomy-triggered hepatocyte regeneration in mice - experimental research. (PubMed, Int J Surg)
SG can enhance hepatic regenerative capacity and improve liver metabolism. This study provides a better understanding of the mechanisms underlying SG-induced metabolic improvements.
Preclinical • Journal
|
YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase)
|
Visudyne (verteporfin)
8ms
Combination of Molecule-Targeted Therapy and Photodynamic Therapy Using Nanoformulated Verteporfin for Effective Uveal Melanoma Treatment. (PubMed, Mol Pharm)
Overall, the results of this preclinical study showed that HANP/VP is an effective nanomedicine for tumor treatment through PDT and inhibition of YAP in the UM tumor mouse model. Combining phototherapy and molecular-targeted therapy offers a promising approach for aggressive UM management.
Journal
|
CD8 (cluster of differentiation 8)
|
Visudyne (verteporfin)
8ms
JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway. (PubMed, Clin Transl Med)
JCAD deficiency leads to an impaired liver growth after PH due to cell division blockage. JCAD competes with LATS2 for WWC1 interaction, resulting in LATS2 inhibition, YAP activation and enhanced expression of cell cycle-associated genes. Delineation of JCADHippoYAP signalling pathway would facilitate to improve prognosis of acute liver failure and graft growth in living-donor liver transplantation.
Journal
|
EGF (Epidermal growth factor) • LATS2 (Large Tumor Suppressor Kinase 2)
|
Visudyne (verteporfin)
8ms
Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy (clinicaltrials.gov)
P4, N=0, Withdrawn, Wake Forest University Health Sciences | N=150 --> 0 | Suspended --> Withdrawn
Enrollment change • Trial withdrawal
|
Visudyne (verteporfin) • Lucentis (ranibizumab)
8ms
FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway. (PubMed, J Ovarian Res)
These effects were completely reversed by the small molecule inhibitor of YAP1-verteporfin (VP). Taken together, these data suggested that FTO-YAP1 plays a positive role in regulating the proliferation of injured granulosa cells induced by cisplatin.
Journal • Tumor cell
|
YAP1 (Yes associated protein 1) • ANKRD1 (Ankyrin Repeat Domain 1) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • CCN1 (Cellular Communication Network Factor 1) • CTGF (Connective tissue growth factor)
|
FTO expression
|
cisplatin • Visudyne (verteporfin)
8ms
YAP upregulates AMPKα1 to induce cancer cell senescence. (PubMed, Int J Biochem Cell Biol)
Treatment with verteporfin inhibited YAP's binding to TEAD and reversed the elevated expression of AMPKα1 in the cells overexpressing CFP-YAP...In addition, the AMPKα1 puncta were demonstrated to inhibit cell viability, autophagy, and proliferation, and ultimately promote cell senescence. In conclusion, YAP binds to TEAD to upregulate AMPKα1 and promotes the formation of AMPKα1 puncta around mitochondria under the condition of co-expression of CFP-YAP and YFP-AMPKα1, in which AMPKα1 puncta lead to cellular senescence.
Journal
|
AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
|
AMPK expression
|
Visudyne (verteporfin)
8ms
New P1/2 trial
|
Visudyne (verteporfin)
9ms
Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma (clinicaltrials.gov)
P1/2, N=24, Recruiting, Emory University | Trial primary completion date: Aug 2024 --> Aug 2025
Trial primary completion date
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation
|
Visudyne (verteporfin)
9ms
YAP induces FAK phosphorylation to inhibit gastric cancer cell proliferation via upregulation of HMGB1. (PubMed, Int J Biol Macromol)
Furthermore, Verteporfin (a small molecule inhibitor of YAP) interrupted the YAP-TEAD interaction and inhibited FAK phosphorylation, confirming that YAP can induce FAK phosphorylation in a TEAD-dependent manner...Silencing HMGB1 reversed YAP-induced FAK activation as well as cell proliferation and migration. Collectively, our results reveal a new signalling axis, YAP/HMGB1/FAK, in the regulation of cell proliferation and migration, and provide new insights into the crosstalk between Hippo signalling and cell proliferation.
Journal
|
YAP1 (Yes associated protein 1) • HMGB1 (High Mobility Group Box 1)
|
YAP1 overexpression
|
Visudyne (verteporfin)
10ms
LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization. (PubMed, Curr Med Sci)
LATS1 may downregulate YAP1-Ser127 phosphorylation and maintain B-ALL cell function; thus, VP, which targets this axis, may serve as a new therapeutic method for improving the outcomes for B-ALL patients.
Journal
|
YAP1 (Yes associated protein 1) • LATS1 (Large Tumor Suppressor Kinase 1)
|
Visudyne (verteporfin)
10ms
A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation. (PubMed, Cancer Lett)
Verteporfin was identified as a more selective and potent antagonist than the known CCR5 antagonist maraviroc. Overall, this study introduced an easy-to-use HTS assay that streamlines the discovery of CCL5/CCR5 axis antagonists. Verteporfin was identified as a specific molecular probe of this axis with great potentials as a therapeutic agent for treating sixteen malignant diseases characterized by heightened CCR5 and YAP1 levels.
Journal • IO biomarker
|
CD8 (cluster of differentiation 8) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • YAP1 (Yes associated protein 1) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • CXCL16 (C-X-C Motif Chemokine Ligand 16)
|
HIF1A expression
|
Visudyne (verteporfin)
10ms
Verteporfin induces lipid peroxidation and ferroptosis in pancreatic cancer cells. (PubMed, Free Radic Biol Med)
Temoporfin, another photodynamic drug, did not show similar activities...Notably, the activity of VP to induce lipid peroxidation was neutralized by ferroptosis inhibitors ferrostatin-1 or liproxstatin-1...These results indicate that VP can induce lipid peroxidation and ferroptosis in the absence of light activation. Our findings reveal a novel mechanism by which VP inhibits tumor growth and provide insights into development of new therapeutic strategies for the treatment of pancreatic cancer.
Journal
|
GPX4 (Glutathione Peroxidase 4)
|
Visudyne (verteporfin) • Foscan (temoporfin) • liproxstatin-1
11ms
Ultrasound-Guided Verteporfin Photodynamic Therapy for the Treatment of Unresectable Solid Pancreatic Tumors or Advanced Pancreatic Cancer, VERTPAC-02 Study (clinicaltrials.gov)
P2, N=13, Completed, Mayo Clinic | Recruiting --> Completed | N=30 --> 13 | Trial completion date: Jul 2024 --> Sep 2023 | Trial primary completion date: Jul 2024 --> Sep 2023
Trial completion • Enrollment change • Trial completion date • Trial primary completion date • Metastases
|
Visudyne (verteporfin)
11ms
Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development. (PubMed, Cell Oncol (Dordr))
Our study revealed a novel mechanism of TAZ nuclear retention regulated by SIRT5-mediated K54 deacetylation and demonstrated the significance of TAZ deacetylation in CTGF expression. This study highlights the potential implications of the SIRT5/TAZ axis for treating metastatic melanoma.
Journal
|
EGF (Epidermal growth factor) • LATS2 (Large Tumor Suppressor Kinase 2) • CTGF (Connective tissue growth factor) • SIRT5 (Sirtuin 5)
|
Visudyne (verteporfin)
11ms
Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy (clinicaltrials.gov)
P4, N=150, Suspended, Wake Forest University Health Sciences | Recruiting --> Suspended
Trial suspension
|
Visudyne (verteporfin) • Lucentis (ranibizumab)
12ms
Oridonin suppresses the growth of glioblastoma cells via inhibiting Hippo/YAP axis. (PubMed, Arch Biochem Biophys)
The YAP inhibitor Verteporfin (VP) and the overexpression of YAP were used to investigate its potential relation with glioma...ORI reversed the effect of overexpression of YAP. Collectively, oridonin suppressed glioblastoma oncogenesis via the Hippo/YAP signaling pathway and could be a potential therapeutic target in the treatment of glioblastoma.
Journal • IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • YAP1 (Yes associated protein 1) • CASP3 (Caspase 3)
|
MYC expression • BAX expression • YAP1 overexpression
|
Visudyne (verteporfin)
12ms
Combination of verteporfin-photodynamic therapy with 5-aza-2'-deoxycytidine enhances the anti-tumour immune response in triple negative breast cancer. (PubMed, Front Immunol)
To our knowledge, this is the first study that shows which of the innate and adaptive immune biomarkers are activated during PDT related treatment of the TNBC 4T1 mouse models. The results also indicate that some of the immune response biomarkers can be used to monitor the effectiveness of PDT treatment in TNBC murine model warranting further investigation in human subjects.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CCL5 (Chemokine (C-C motif) ligand 5) • CCL2 (Chemokine (C-C motif) ligand 2) • GZMA (Granzyme A) • BCL3 (BCL3 Transcription Coactivator) • PRF1 (Perforin 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1)
|
BCL2 expression • CD8 expression • CD4 expression
|
Visudyne (verteporfin)
1year
BRD4/nuclear PD-L1/RelB circuit is involved in the stemness of breast cancer cells. (PubMed, Cell Commun Signal)
The results show the first evidence of the essential role of the BRD4/nuclear PD-L1/RelB axis in breast CSC formation. The nuclear PD-L1 regulates RelB, and the RelB/p65 complex induces IL6 and breast CSC formation. Targeting nuclear PD-L1 represents a potential and novel tool for immunotherapies of intractable BC. Video Abstract.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • IL6 (Interleukin 6) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • BRD4 (Bromodomain Containing 4) • RELB (RELB Proto-Oncogene)
|
PD-L1 expression • IL6 expression
|
JQ-1 • Visudyne (verteporfin) • ARV-825
1year
Silencing GMPPB Inhibits the Proliferation and Invasion of GBM via Hippo/MMP3 Pathways. (PubMed, Int J Mol Sci)
Finally, we identify that the Hippo/MMP3 axis is essential for GMPPB-promoted GBM aggressiveness. These findings indicate that GMPPB represents a potential novel target for GBM treatment.
Journal
|
MMP3 (Matrix metallopeptidase 3) • GMPPB (GDP-Mannose Pyrophosphorylase B)
|
Visudyne (verteporfin)
1year
Verteporfin Suppresses YAP-Induced Glycolysis in Breast Cancer Cells. (PubMed, J Invest Surg)
Treatment with VP effectively suppressed glycolysis induced by YAP overexpression in BC cells. VP exhibited anti-glycolytic effect on BC cells, indicating its therapeutic value as an FDA-approved drug.
Journal
|
YAP1 (Yes associated protein 1)
|
Visudyne (verteporfin)
1year
Photodynamic therapy with verteporfin accelerates apoptotic bleb formation in human ameloblastoma. (PubMed, Oral Dis)
VP PDT has the potential to become an additional treatment for large-sized ameloblastoma.
Journal
|
LDLR (Low Density Lipoprotein Receptor)
|
Visudyne (verteporfin)
1year
Application of singlet oxygen-activatable nanocarriers to boost X-ray-induced photodynamic therapy and cascaded ferroptosis for breast cancer treatment. (PubMed, J Mater Chem B)
To realize combined X-PDT and ferroptosis, a nanocarrier (D-NP) was engineered with a hyperbranched copolymer with O-sensitive linkers, where both the photosensitizer (verteporfin) and ferroptosis inducer RAS-selective lethal small molecule 3 (RSL3) were encapsulated. Tumor growth inhibition in murine 4T1 tumor-bearing mice demonstrated that D-NP produced pronounced therapeutic efficiency where ferroptosis induction was supported by the GPX4 content and expression. This study highlights the contribution of O-sensitive nanocarriers for promoting the potency of combined X-PDT and ferroptosis.
Journal
|
GPX4 (Glutathione Peroxidase 4)
|
Visudyne (verteporfin) • RSL3