P2, N=25, Not yet recruiting, Washington University School of Medicine

The mOS of the EGFR-TP53 co-mutant group who received second-line TKIs combined with platinum-containing double-drug chemotherapy and bevacizumab after the progression of first-line single-drug TKIs was 27.0 months versus 6.0 months compared with those who did not receive second-line therapy (P = .019). In first-line EGFR-TKIs monotherapy in patients with EGFR-TP53 co-mutation, osimertinib was clearly superior to gefitinib. In first-line EGFR-TKIs monotherapy progression, TKIs combined with chemotherapy and antiangiogenesis therapy could prolong patients' survival.

The addition of bevacizumab to chemoimmunotherapy was associated with improved survival in ns-NSCLC specifically in patients with LMs. These hypothesis-generating findings suggest that the benefit may stem from disruption of VEGF-A-driven immunosuppressive signaling in the liver, but require prospective confirmation.

P1/2, N=380, Recruiting, BioNTech SE | Trial completion date: May 2029 --> Aug 2029 | Trial primary completion date: May 2028 --> Aug 2029

P1/2, N=388, Completed, Genentech, Inc. | Trial completion date: Apr 2027 --> Jun 2026 | Trial primary completion date: Apr 2027 --> May 2026 | Active, not recruiting --> Completed

P2, N=36, Not yet recruiting, Fudan University

P2, N=155, Active, not recruiting, University Health Network, Toronto | Trial primary completion date: Apr 2026 --> Dec 2026

P2, N=202, Active, not recruiting, University Hospital, Montpellier | Recruiting --> Active, not recruiting

This study has confirmed that V-SH/Lys nanoparticles, by targeting and regulating VEGF-A, provide an efficient, safe and non-invasive treatment strategy for CNV, and have potential for clinical application.

P1/2, N=54, Recruiting, Washington University School of Medicine | Not yet recruiting --> Recruiting

The addition of ipilimumab to atezolizumab plus bevacizumab did not show any benefit in patients with previously untreated, unresectable hepatocellular carcinoma. These results do not support the addition of low-dose (1 mg/kg) ipilimumab to atezolizumab plus bevacizumab as a first-line treatment in this setting.

A total of six cycles of pemetrexed-cisplatin chemotherapy were given and elicited a partial response. The disease progressed and intraperitoneal bevacizumab-cisplatin therapy was administered, which was ineffective...Correct diagnosis is facilitated by an awareness of occupational exposure risk, such as that of asphalt exposure for the present case, and early histopathological evaluation. The prognosis for DPM remains poor despite multimodal therapy, and novel therapeutic strategies are needed.