^
Contact us  to learn more about
our Premium Content:  News alerts, weekly reports and conference planners
DRUG CLASS:

VEGF-A inhibitor

Related drugs:
Phase 2
BeiGene
Completed
Last update posted :
02/24/2025
Initiation :
08/20/2021
Primary completion :
02/01/2024
Completion :
02/01/2024
PD-L1
|
PD-L1 expression
|
Tevimbra (tislelizumab-jsgr) • Avzivi (bevacizumab-tnjn) • ociperlimab (BGB-A1217)
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
11/02/2007
Primary completion :
01/07/2014
Completion :
02/22/2025
HER-2 • ER
|
Avastin (bevacizumab) • paclitaxel • doxorubicin hydrochloride • cyclophosphamide • Aybintio (bevacizumab biosimilar) • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • Zirabev (bevacizumab-bvzr) • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar) • cyclophosphamide intravenous
Phase 2
The First Affiliated Hospital with Nanjing Medi...
Not yet recruiting
Last update posted :
02/19/2025
Initiation :
02/01/2025
Primary completion :
02/01/2027
Completion :
05/01/2027
BRAF
|
Avastin (bevacizumab) • Tevimbra (tislelizumab-jsgr) • capecitabine • oxaliplatin
Phase N/A
Centre Hospitalier Universitaire de Nīmes
Recruiting
Last update posted :
02/14/2025
Initiation :
10/01/2020
Primary completion :
05/31/2025
Completion :
09/30/2025
BRCA
|
Avastin (bevacizumab) • Zejula (niraparib)
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/14/2025
Initiation :
09/06/2005
Primary completion :
08/31/2025
Completion :
08/31/2025
MSI • MSH2
|
Avastin (bevacizumab) • 5-fluorouracil • oxaliplatin • leucovorin calcium • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • Zirabev (bevacizumab-bvzr) • Jobevne (bevacizumab-nwgd) • fluorouracil topical • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar)
Phase 2
Yonsei University
Recruiting
Last update posted :
02/14/2025
Initiation :
01/22/2024
Primary completion :
08/31/2027
Completion :
12/31/2029
MSI • PD-1 • WT1
|
Avastin (bevacizumab) • gemcitabine • paclitaxel • doxorubicin hydrochloride • Jemperli (dostarlimab-gxly) • pegylated liposomal doxorubicin
Phase 3
Georgetown University
Recruiting
Last update posted :
02/13/2025
Initiation :
03/29/2023
Primary completion :
12/01/2026
Completion :
12/01/2028
CD4
|
Avastin (bevacizumab) • Tecentriq (atezolizumab)
Phase 2
Fundación GECP
Completed
Last update posted :
02/13/2025
Initiation :
05/15/2019
Primary completion :
10/21/2024
Completion :
10/21/2024
TMB
|
Avastin (bevacizumab) • Tecentriq (atezolizumab)
Phase 1/2
City of Hope Medical Center
Active, not recruiting
Last update posted :
02/12/2025
Initiation :
05/03/2023
Primary completion :
10/07/2025
Completion :
10/07/2025
POLE
|
POLE mutation
|
Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • balstilimab (AGEN2034) • botensilimab (AGEN1181) • fluorouracil topical
Phase 2
Cancer Institute and Hospital, Chinese Academy ...
Recruiting
Last update posted :
02/11/2025
Initiation :
08/15/2020
Primary completion :
07/01/2026
Completion :
07/01/2028
EGFR • HER-2 • BRAF • ALK • MET • BRCA1 • BRCA2 • KIT • ROS1 • CDKN2A
|
BRCA2 mutation • BRCA1 mutation • EGFR mutation • HER-2 overexpression • BRAF mutation • HER-2 amplification • MET amplification • KIT mutation • ALK fusion • ROS1 fusion • CDKN2A mutation • MET mutation • BRAF amplification
|
Xalkori (crizotinib) • Tecentriq (atezolizumab) • Ibrance (palbociclib) • Zelboraf (vemurafenib) • imatinib • Tyvyt (sintilimab) • Alecensa (alectinib) • Zejula (niraparib) • Irene (pyrotinib) • Ameile (aumolertinib) • Vizimpro (dacomitinib)
Phase 3
ARCAGY/ GINECO GROUP
Completed
Last update posted :
02/11/2025
Initiation :
09/22/2016
Primary completion :
10/15/2021
Completion :
02/22/2024
PD-L1
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • carboplatin • paclitaxel • doxorubicin liposomal
Phase 2
Chinese PLA General Hospital
Recruiting
Last update posted :
02/11/2025
Initiation :
04/16/2022
Primary completion :
01/20/2025
Completion :
06/01/2025
HER-2 • PD-L1
|
HER-2 negative
|
Avastin (bevacizumab) • Tevimbra (tislelizumab-jsgr) • capecitabine • oxaliplatin
Phase 2/3
Bio-Thera Solutions
Recruiting
Last update posted :
02/10/2025
Initiation :
12/13/2023
Primary completion :
09/01/2026
Completion :
01/01/2027
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • cisplatin • carboplatin • paclitaxel • Avzivi (bevacizumab-tnjn) • BAT1308
Phase 2
Shanghai Gynecologic Oncology Group
Recruiting
Last update posted :
02/10/2025
Initiation :
07/13/2022
Primary completion :
06/01/2027
Completion :
06/01/2027
HRD • BRCA
|
HRD
|
Avastin (bevacizumab) • Lynparza (olaparib) • carboplatin • paclitaxel • docetaxel • Zejula (niraparib)
Phase 1
M.D. Anderson Cancer Center
Recruiting
Last update posted :
02/10/2025
Initiation :
06/23/2020
Primary completion :
12/31/2026
Completion :
12/31/2026
PIK3CA • PTEN
|
PIK3CA mutation
|
Avastin (bevacizumab) • 5-fluorouracil • oxaliplatin • Torisel (temsirolimus) • pegylated liposomal doxorubicin • leucovorin calcium • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin) • fluorouracil topical • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar) • doxorubicin liposomal
Phase 2
Henan Cancer Hospital
Recruiting
Last update posted :
02/10/2025
Initiation :
11/06/2024
Primary completion :
11/06/2025
Completion :
11/06/2025
CD8 • PD-1 • VEGFA • CD4 • FGF • GZMB • TGFB1 • CD31 • PECAM1
|
Avastin (bevacizumab) • carboplatin • AiRuiKa (camrelizumab)
Phase 2
M.D. Anderson Cancer Center
Active, not recruiting
Last update posted :
02/07/2025
Initiation :
11/15/2016
Primary completion :
02/01/2026
Completion :
02/01/2026
MUC16
|
Avastin (bevacizumab)
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/06/2025
Initiation :
10/12/2010
Primary completion :
02/25/2015
Completion :
03/01/2025
KRAS
|
KRAS mutation
|
Avastin (bevacizumab) • carboplatin • paclitaxel • capecitabine • oxaliplatin • Aybintio (bevacizumab biosimilar) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn)
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/06/2025
Initiation :
05/15/2009
Primary completion :
08/01/2014
Completion :
02/22/2025
HER-2 • ER • PGR
|
HER-2 negative
|
Avastin (bevacizumab) • carboplatin • paclitaxel • doxorubicin hydrochloride • cyclophosphamide • Aybintio (bevacizumab biosimilar) • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • Zirabev (bevacizumab-bvzr) • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar) • cyclophosphamide intravenous
Phase 3
Dutch Colorectal Cancer Group
Completed
Last update posted :
02/06/2025
Initiation :
07/01/2014
Primary completion :
07/01/2022
Completion :
01/01/2025
BRAF • RAS
|
BRAF mutation • RAS mutation
|
Avastin (bevacizumab) • 5-fluorouracil • Vectibix (panitumumab) • oxaliplatin • irinotecan • leucovorin calcium
Phase 2
Georgetown University
Recruiting
Last update posted :
02/06/2025
Initiation :
12/21/2021
Primary completion :
12/01/2025
Completion :
12/01/2025
ALK • ROS1
|
PD-L1 expression • ALK wild-type • ROS1 wild-type
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • tiragolumab (RG6058)
Phase 2
UNC Lineberger Comprehensive Cancer Center
Completed
Last update posted :
02/06/2025
Initiation :
05/01/2014
Primary completion :
08/01/2024
Completion :
08/01/2024
UGT1A1
|
UGT1A1*1*1
|
Avastin (bevacizumab) • 5-fluorouracil • irinotecan • leucovorin calcium • Mvasi (bevacizumab-awwb)
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/06/2025
Initiation :
09/24/2008
Primary completion :
06/30/2014
Completion :
05/30/2025
ER • PGR
|
ER expression
|
Avastin (bevacizumab) • letrozole • Aybintio (bevacizumab biosimilar) • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • Zirabev (bevacizumab-bvzr) • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Soltamox (tamoxifen citrate) • Vasforda (bevacizumab biosimilar)
Phase 3
Japanese Foundation for Cancer Research
Active, not recruiting
Last update posted :
02/05/2025
Initiation :
01/21/2021
Primary completion :
09/30/2025
Completion :
09/30/2025
HER-2 • PD-L1
|
HR positive • HER-2 negative
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • paclitaxel
Phase 2
John Hays
Completed
Last update posted :
02/05/2025
Initiation :
02/01/2013
Primary completion :
08/06/2018
Completion :
08/06/2018
KRAS
|
KRAS mutation • NRAS mutation • RAS mutation
|
Avastin (bevacizumab) • 5-fluorouracil • Vectibix (panitumumab) • irinotecan • leucovorin calcium
Phase 1/2
St. Jude Children's Research Hospital
Recruiting
Last update posted :
02/04/2025
Initiation :
11/07/2022
Primary completion :
06/01/2032
Completion :
06/01/2037
PD-L1
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • sorafenib • cyclophosphamide
Phase 3
Istituto Scientifico Romagnolo per lo Studio e ...
Completed
Last update posted :
01/31/2025
Initiation :
11/01/2007
Primary completion :
03/01/2014
Completion :
06/11/2016
KRAS
|
Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium
Phase 2
University of Texas Southwestern Medical Center
Recruiting
Last update posted :
01/29/2025
Initiation :
12/19/2023
Primary completion :
10/01/2026
Completion :
10/01/2028
BRAF • MSI • MLH1 • MSH6 • MSH2 • CD4
|
BRAF V600E • BRAF V600 • RAS wild-type
|
Avastin (bevacizumab) • Tecentriq (atezolizumab)
Phase 2
Kamya Sankar
Recruiting
Last update posted :
01/22/2025
Initiation :
07/15/2024
Primary completion :
12/28/2026
Completion :
12/28/2027
EGFR
|
EGFR mutation
|
Avastin (bevacizumab) • Tecentriq (atezolizumab) • carboplatin
Phase 1/2
BeiGene
Active, not recruiting
Last update posted :
01/01/2025
Initiation :
01/29/2023
Primary completion :
04/15/2026
Completion :
04/15/2026
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • 5-fluorouracil • Tevimbra (tislelizumab-jsgr) • capecitabine • Avzivi (bevacizumab-tnjn) • alcestobart (LBL-007)
Phase 3
Shanghai Henlius Biotech
Completed
Last update posted :
12/31/2024
Initiation :
04/09/2018
Primary completion :
04/15/2020
Completion :
04/20/2023
BRAF
|
Avastin (bevacizumab) • 5-fluorouracil • capecitabine • oxaliplatin • leucovorin calcium • Hanbeitai (bevacizumab biosimilar)
Phase 2
Li-kun Chen
Recruiting
Last update posted :
12/11/2024
Initiation :
09/04/2024
Primary completion :
02/01/2028
Completion :
02/01/2028
EGFR
|
EGFR mutation
|
Avastin (bevacizumab) • Ivesa (firmonertinib)
Phase 2
University of California, Irvine
Active, not recruiting
Last update posted :
12/09/2024
Initiation :
04/01/2015
Primary completion :
06/01/2025
Completion :
06/01/2025
HER-2
|
HER-2 positive • HER-2 negative
|
Avastin (bevacizumab) • Herceptin (trastuzumab) • carboplatin • paclitaxel • Perjeta (pertuzumab)
Phase 1/2
Biotheus Inc.
Recruiting
Last update posted :
12/03/2024
Initiation :
07/01/2022
Primary completion :
10/30/2026
Completion :
10/30/2026
HER-2 • PGR
|
HER-2 negative • ER negative
|
albumin-bound paclitaxel • BNT327
Phase 4
yangjianjun
Recruiting
Last update posted :
11/12/2024
Initiation :
09/01/2024
Primary completion :
01/15/2025
Completion :
01/15/2026
BRAF
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • capecitabine • oxaliplatin
Phase 1/2
Roswell Park Cancer Institute
Active, not recruiting
Last update posted :
11/06/2024
Initiation :
11/21/2012
Primary completion :
05/02/2025
Completion :
05/02/2025
CXCL8
|
Avastin (bevacizumab) • pazopanib
Phase 2
Dana-Farber Cancer Institute
Active, not recruiting
Last update posted :
10/30/2024
Initiation :
11/10/2016
Primary completion :
01/01/2025
Completion :
01/01/2027
BRCA
|
BRCA mutation
|
Opdivo (nivolumab) • Avastin (bevacizumab) • Rubraca (rucaparib)
Phase 2
British Columbia Cancer Agency
Not yet recruiting
Last update posted :
10/23/2024
Initiation :
11/01/2024
Primary completion :
05/01/2026
Completion :
11/01/2028
BRCA
|
Avastin (bevacizumab) • Lynparza (olaparib) • Imfinzi (durvalumab)
Phase 2/3
Shanghai Henlius Biotech
Recruiting
Last update posted :
10/17/2024
Initiation :
03/10/2021
Primary completion :
09/24/2025
Completion :
12/30/2026
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • capecitabine • oxaliplatin • Hetronifly (serplulimab) • Hanbeitai (bevacizumab biosimilar)
Phase 2
Chang Gung Memorial Hospital
Not yet recruiting
Last update posted :
09/24/2024
Initiation :
09/30/2024
Primary completion :
06/30/2029
Completion :
09/30/2031
ITGAM
|
Avastin (bevacizumab) • Tecentriq (atezolizumab)
Phase 4
Anhui Provincial Hospital
Active, not recruiting
Last update posted :
09/11/2024
Initiation :
12/19/2023
Primary completion :
03/01/2026
Completion :
03/01/2026
PD-L1
|
Avastin (bevacizumab) • Tyvyt (sintilimab)